Abstract:In this study, we proposed an efficient algorithm (X-LD) for estimating LD patterns for a genomic grid, which can be of inter-chromosomal scale or of a pair of small segments. Compared with conventional methods, the proposed method was significantly faster, and consequently we were permitted to explore in depth unknown or reveal long-anticipated LD features of the human genome. Having applied the algorithm as demonstrated in 1000 Genome Project (1KG), we found: I) The extended LD, driven by population structur… Show more
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