2020
DOI: 10.1002/ange.202010006
|View full text |Cite
|
Sign up to set email alerts
|

Efficient Encounter Complex Formation and Electron Transfer to Cytochrome c Peroxidase with an Additional, Distant Electrostatic Binding Site

Abstract: Electrostatic interactions can strongly increase the efficiency of protein complex formation. The charge distribution in redoxp roteins is often optimizedt os teer ar edox partner to the electron transfer active binding site.T ot est whether the optimizeddistribution is more important than the strength of the electrostatic interactions,anadditional negative patch was introduced on the surface of cytochrome cp eroxidase,a way from the stereospecific binding site,a nd its effect on the encounter complex as well … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

1
28
2

Year Published

2021
2021
2022
2022

Publication Types

Select...
4
1

Relationship

3
2

Authors

Journals

citations
Cited by 5 publications
(31 citation statements)
references
References 52 publications
1
28
2
Order By: Relevance
“… 30 CcP_B additionally has the K21E, K29E, K90E, and K97E mutations. 27 CcP_C contains the same mutations as CcP_B and D35N, E36Q, E119Q, E202Q, E210Q, E215Q, D225N, and E291Q that neutralize the charges of the WT binding site. CcP_D has mutations K75E, K76Q, N79D, Q87E, K91Q, K98Q, and N142D in comparison to CcP_A.…”
Section: Methodsmentioning
confidence: 99%
See 4 more Smart Citations
“… 30 CcP_B additionally has the K21E, K29E, K90E, and K97E mutations. 27 CcP_C contains the same mutations as CcP_B and D35N, E36Q, E119Q, E202Q, E210Q, E215Q, D225N, and E291Q that neutralize the charges of the WT binding site. CcP_D has mutations K75E, K76Q, N79D, Q87E, K91Q, K98Q, and N142D in comparison to CcP_A.…”
Section: Methodsmentioning
confidence: 99%
“…The structures were prepared, and the Monte Carlo docking simulations were performed as described in ref ( 27 ). The structures of CcP and Cc from Protein Data Bank (PDB) entry 2PCC( 16 ) were used as a basis for the simulations.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations