Efficient Encapsulation of β-Lapachone into Self-Immolative Polymer Nanoparticles for Cyclic Amplification of Intracellular Reactive Oxygen Species Stress
Lingxiao Guo,
Zexuan Ding,
Jinming Hu
et al.
Abstract:The selective upregulation of intracellular oxidative
stress in
cancer cells presents a promising approach for effective cancer treatment.
In this study, we report the integration of enzyme catalytic amplification
and chemical amplification reactions in β-lapachone (Lap)-loaded
micellar nanoparticles (NPs), which are self-assembled from reactive
oxygen species (ROS)-responsive self-immolative polymers (SIPs). This
integration enables cyclic amplification of intracellular oxidative
stress in cancer cells. Speci… Show more
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