“…[33][34][35][36][37][38] SomeD NA intercalative Ru II complexes have been previously reported to induce DNA B-Z conformational transfer, [39][40][41][42] as well as some Ru II DNA intercalating complexes,w hichc an con-denseD NA. [42][43][44][45][46][47] In this work,o ur results serve to demonstrate the structurale ffect of DNA intercalators on their interference with DNA high-order structures, and to determine the link betweent he B-Z DNA conformational transformation andD NA condensation. Therefore, as eries of chiral polypyridyl Ru II complexesw ith expanding planar ligands ([Ru(bpy) 2 IP](ClO 4 ) 2 (D-Ru1 and L-Ru1), [Ru(bpy) 2 IIP](ClO 4 ) 2 (D-Ru2 and L-Ru2), and [Ru(bpy) 2 NIP](ClO 4 ) 2 (D-Ru3 and L-Ru3)( Scheme 1, bpy = 2,2'bipyridine, IP = imidazo [4,5-f] [1,10]phenanthroline, IIP = isoindolylimidazo [4,5,f] [1,10]phenanthroline, NIP = benzo[f]isoindole [4,5,f] [1,10]phenanthroline)) are synthesized and characterized, andt heir structural effects on DNA are studiedb yu sing spectraland morphological tools.…”