Efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor

Abstract

A Eu(iii)–MOF sensor with intense red luminescence can effectively probe bilirubin in water through fluorescence decay, and can be fabricated into portable test papers to achieve visualized detection of bilirubin.

Designed Tb(III)-Functionalized MOF-808 as Visible Fluorescent Probes for Monitoring Bilirubin and Identifying Fingerprints

“…Up to present, fluorescence probes as powerful sensing tools have aroused a remarkable concern in virtue of high sensitivity, excellent selectivity, and fast response time, which have been devised as efficient fluorescent probes for clinical diagnosis and biological labeling. − At present, a few fluorescent probes have been reported for sensing BR, which are derived from BamD, a polyfluorene polymer, nanosheet-tta/PS, PF-Ph-GlcA, protein (rI-FABP), PDPPF- co -Ph, HSA-AuNCs, Mn:ZnS QDs, MoS 2 QDs, Eu­(ettfd) 3 , and Eu 3+ -MOFs. − Among these fluorescence sensors, lanthanide metal–organic frameworks (Ln 3+ -MOFs) have more abundant active sites that chelate a series of Ln 3+ and display fascinating distinctive features in virtue of the Ln 3+ f–f electronic transition and ligand-to-metal energy transfer (LMET). , Benefiting from the excellent optical and spectral properties, and diversified sensing mechanisms, a Ln 3+ -MOF fluorescent probe has shown remarkable sensing performance for cations and anions, biomarkers, organic small molecules, gases, organophosphorus pesticides, nitro-explosives, and antibiotics. − However, the development of Ln 3+ -MOF recognition platforms with fast response, and high sensitivity and selectivity is still an urgent demand for sensing biomarkers with a function of indicating human health in the present.…”

Fabrication of a Stable Europium-Based Luminescent Sensor for Fast Detection of Urinary 1-Hydroxypyrene Constructed from a Tetracarboxylate Ligand

“…In fact, considerable efforts have been dedicated to seeking simple and effective methods on detecting urinary 1-HP for the past few years. Benefitting from the fascinating fluorescent capabilities such as characteristic and strong emission peaks, long lifetimes, high quantum yields, and large Stokes shift, − metal–organic frameworks constructed from lanthanide (Ln-MOFs), especially Eu-centered and Tb-centered MOFs featuring the typical red or green luminescence of Eu­(III) and Tb­(III), have been successfully explored and widely applied in chemical sensors, covering metal ions, − anions, − organic molecules, − antibiotics, − temperature variation, and luminescent devices. − Yan’s group reported a luminescent Eu-doped Ga-MOF applied as a fast-responsive, highly sensitive, and selective sensor for detecting 1-HP . Liu and coworkers developed an Eu 3+ -incorporated Zn-MOF considered as a potential ratiometric luminescent probe for 1-HP .…”

Isostructural Lanthanide Coordination Polymers with High Photoluminescent Quantum Yields by Effective Ligand Combination: Crystal Structures, Photophysical Characterizations, Biologically Relevant Molecular Sensing, and Anti-Counterfeiting Ink Application

“…The PXRD profiles of the recovered powder change insignificantly (Figure ), unraveling their persistent water stability in a relatively wide pH interval. Compared with the known lanthanide complexes with promising fluorescent sensing performance in a water system and/or in mixed organic solvents, ,,− the excellent water stability of Tb-CP and Eu-CP is more significantly due to the hydrophobic effect of the conjugated TPA ligand, not the strong binding ability between Ln III ions and N or O donors judging from their comparable bond lengths.…”

“…These separate emissions are arising from the characteristic 5 D 4 → 7 F J ( J = 6–3) jumps of the Tb III site. , The electric dipole-induced 5 D 4 → 7 F 5 transition with the strongest intensity emits an intense green light easily visualized with the naked eyes assisted through the portable UV lamp excitation (inset of Figure a). Upon excitation at 394 nm, the Eu-CP exhibits well-defined hypersensitive spectral lines at 579, 593, 616, 651, as well as 692 nm, assigning, respectively, to the feature 5 D 0 → 7 F J transitions of the Eu III ion ( J = 0–4). − The weak 5 D 0 → 7 F 0 jump is generated by the J -mixing effect of the crystal field, which is permissible for the Eu III ion with C 4 v symmetry . The emission band situated at 593 nm generates from the magnetic dipole movement of 5 D 0 → 7 F 1 and is easily influenced by the coordination surroundings of the Eu III center.…”

“…The decay curves of I 0 / I at 542 nm accord with the first-order exponential equation at low concentrations of HT and HIAA, indicating a diffusion-dominated quenching mechanism (Figure b and Figure S8). With the increasing HT and HIAA ([HT] > 0.16 mM and [HIAA] > 0.23 mM), the plots of I 0 / I vs [analyte] are slightly far from the straight line relationship and bent upward due mainly to self-absorption or energy-shift mechanism. − , Quantitative regression of the linear portions of I 0 /I versus [HT] and I 0 /I versus [HIAA] to the Stern–Volmer (S–V) equation I 0 / I = K SV [M] + 1 (where [M] refers to the molar concentration of the analyte, I 0 and I represent the luminescence intensity in the absence and presence of the analyte) affords the Stern–Volmer quenching constant K SV (L·mol –1 ). , For the HT, a linear equation I 0 / I = 8953.5 [HT] + 1.0148 is obtained, giving a correlation coefficient R 2 = 0.9982 at a low concentration range (<164 μM). For the HIAA, the linear correlation is I 0 / I = 11799.6 [HIAA] + 1.0226 with R 2 = 9955 below 228 μM (Figure S8).…”