Efficient Delivery of Triptolide Plus a miR-30-5p Inhibitor Through the Use of Near Infrared Laser Responsive or CADY Modified MSNs for Efficacy in Rheumatoid Arthritis Therapeutics

Zhang, Xiaonan; Zhang, Xin; Wang, Tao; Bai, Bin; Zhang, Na; Zhao, Yuemin; Yu, Yang; Wang, Bing

doi:10.3389/fbioe.2020.00170

Cited by 15 publications

(12 citation statements)

References 48 publications

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“…This nanosystem could be used to treat osteoarthritis in vivo through intra-articular injection and the NIR light could control dexamethasone release remotely in the disease region, which could be modulated by adjusting the light‑radiation behavior. Similarly, cell membrane penetrating peptide‑modified mesoporous silica nanoparticles (MSNs) were reported to realize the efficient controlled release of triptolide, which is a traditional Chinese herbal medicine used to treat RA 100 . The MSNs modified with indocyanine green, a kind of photothermal agent, could effectively regulate the release of triptolide under 808 nm laser irradiation, leading to the development of noninvasive therapeutic approaches for RA.…”

Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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“…The amount of miR loaded was confirmed by using a NanoDrop 3000 photometer ( Zhang et al, 2020 ). The miR encapsulation efficiency (EE %) of ZIF-8 and FA@ZIF-8 was calculated with the following equation:

…”

Section: Methodsmentioning

confidence: 99%

“…The release system was then maintained at 37°C with vibration (vibration frequency = 100 RPM). The release percentage of miR-491-5p was determined using a NanoDrop3000 photometer ( Zhang et al, 2020 ), and then the samples were transferred back into the original release system. The drug loading capacity of miR-491-5p was determined using a NanoDrop3000 photometer.…”

Section: Methodsmentioning

confidence: 99%

Folic Acid–Modified miR-491-5p–Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Epoxide hydrolase 1 (EPHX1) has been reported to be related to the development of several tumors. However, the regulation of castration-resistant prostate cancer (CRPC) development by EPHX1 has not been reported. We used proteomic technology and found that the EPHX1 protein was highly expressed in CRPC tissues and the CRPC cell line C4-2. We performed screening and found that EPHX1 is a direct target of miR-491-5p. High miR-491-5p expression significantly reduced the EPHX1 level in C4-2 cells and inhibited C4-2 cell proliferation and migration. Zeolite imidazolate framework-8 (ZIF-8) has good thermal stability, a simple synthesis method, tumor site stability, and specific acid responsiveness. We synthesized ZIF-8 nanodrug vectors to deliver miR-491-5p into C4-2 cells. After loading miR-491-5p into ZIF-8, we modified the ZIF-8 surface with folic acid (FA) as the target group (FA@ZIF-8). Our synthesized nanodrug carrier showed less cytotoxicity to C4-2 cells even at 200 μg/ml. Modified FA could increase the efficiency of nanomaterial entry into C4-2 cells. FA@miR-491-5p@ZIF-8 could stably release miR-491-5p for a long period in both phosphate-buffered saline (pH 7.4) and acetate buffer (pH 4.8), and miR-491-5p was released faster at the beginning of the experiment in acetate buffer (pH 4.8). FA@miR-491-5p@ZIF-8 significantly reduced C4-2 cell proliferation and migration, and FA@miR-491-5p@ZIF-8 had a better effect than miR-491-5p alone. In vivo, FA@miR-491-5p@ZIF-8 significantly inhibited CRPC growth in nude mice. Overall, we verified that miR-491-4p regulated CRPC development by targeting EPHX1. The drug nanocarrier FA@miR-491-5p@ZIF-8 not only significantly reduced C4-2 CRPC cell proliferation and migration but also significantly inhibited CRPC growth. Our research provides a theoretical basis for treatment and treatment strategies for CRPC.

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“…MSNs@PCM@TP 100 μg/mL (i.p.) collagen-induced arthritis in rats in vivo RA FLS cells in vitro ↓Proliferation ↑Apoptosis ↓Immune system activation in rats [84] Triptolide loaded by a polyc-glutamic acid-grafted lphenylalanine ethyl ester copolymer 6. 25 Evidence-Based Complementary and Alternative Medicine 4 in human and bovine chondrocytes, SW1353 cells, and synovial fibroblasts, triptolide inhibited cytokine-induced MMP-3 and MMP-13 gene expression in primary human OA chondrocytes, bovine chondrocytes, SW1353 cells, and human syn [80].…”

Section: Cytokine Targeting Diterpenes and Eir Derivativesmentioning

confidence: 99%

Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis

Islam

Quispe

Herrera‐Bravo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Diterpenes and their derivatives have many biological activities, including anti-inflammatory and immunomodulatory effects. To date, several diterpenes, diterpenoids, and their laboratory-derived products have been demonstrated for antiarthritic activities. This study summarizes the literature about diterpenes and their derivatives acting against rheumatoid arthritis (RA) depending on the database reports until 31 August 2021. For this, we have conducted an extensive search in databases such as PubMed, Science Direct, Google Scholar, and Clinicaltrials.gov using specific relevant keywords. The search yielded 2708 published records, among which 48 have been included in this study. The findings offer several potential diterpenes and their derivatives as anti-RA in various test models. Among the diterpenes and their derivatives, andrographolide, triptolide, and tanshinone IIA have been found to exhibit anti-RA activity through diverse pathways. In addition, some important derivatives of triptolide and tanshinone IIA have also been shown to have anti-RA effects. Overall, findings suggest that these substances could reduce arthritis score, downregulate oxidative, proinflammatory, and inflammatory biomarkers, modulate various arthritis pathways, and improve joint destruction and clinical arthritic conditions, signs, symptoms, and physical functions in humans and numerous experimental animals, mainly through cytokine and chemokine as well as several physiological protein interaction pathways. Taken all together, diterpenes, diterpenoids, and their derivatives may be promising tools for RA management.

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Efficient Delivery of Triptolide Plus a miR-30-5p Inhibitor Through the Use of Near Infrared Laser Responsive or CADY Modified MSNs for Efficacy in Rheumatoid Arthritis Therapeutics

Cited by 15 publications

References 48 publications

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Folic Acid–Modified miR-491-5p–Loaded ZIF-8 Nanoparticles Inhibit Castration-Resistant Prostate Cancer by Regulating the Expression of EPHX1

Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis

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