Efficient Delivery of Therapeutic Agents by Using Targeted Albumin Nanoparticles

Kouchakzadeh, Hasan; Safavi, Maryam Sadat; Shojaosadati, Seyed Abbas

doi:10.1016/bs.apcsb.2014.11.002

Cited by 52 publications

(33 citation statements)

References 88 publications

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“…Several methods have been proposed to classify albumin–drug conjugates such as those based on fabrication methods [21], the structure of NPs [9,55] or the structure of the NP–drug conjugate [9,21,99], and the type of interaction [21], receptors [100], or target tissue [9,16] and improvement of drug half-life [100]. In the present work, we divide these conjugates based on the water solubility of the drugs that have been encapsulated.…”

Section: Albumin Conjugates For Drug Deliverymentioning

confidence: 99%

“…In addition, several clinical trials are under development for treatment of metastatic melanoma, pancreatic cancer and for delivery of other hydrophilic/hydro-phobic drugs [16,21]. The regulatory approvals that have already been obtained for several albumin-based therapeutic agents suggest this approach will continue to be a profitable route for future endeavors.…”

Section: Expert Opinionmentioning

confidence: 99%

“…Besides, albumin has been shown to have a high capacity of binding to a wide variety of drugs [9]. In this regard, in medicinal therapeutic approaches, drug delivery systems (DDSs) based on colloidal albumin NPs have attracted much attention due to their advantages including a high drug loading and entrapment capacity, good biocompatibility and biodegradability [20,21]. Furthermore, albumin nanocarriers are considered to be reliable and efficient carrier systems with features such as facile preparation, controllable well-defined size, and desirable surface modification characteristics [21].…”

Section: Introductionmentioning

confidence: 99%

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Albumin nanostructures as advanced drug delivery systems

Karimi

Bahrami

Ravari

et al. 2016

Expert Opinion on Drug Delivery

307

190

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Introduction One of the biggest impacts that the nanotechnology has made on medicine and biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability in biological environments, poor uptake into cells and tissues, suboptimal selectivity for targets and unwanted side effects. Nanocarriers can be designed as DDSs to overcome many of these drawbacks. One of the most versatile building blocks to prepare these nanocarriers is the ubiquitous, readily available and inexpensive protein, serum albumin. Areas covered This review covers the use of different types of albumin (human, bovine, rat, and chicken egg) to prepare nanoparticle and microparticle-based structures to bind drugs. Various methods have been used to modify the albumin structure. A range of targeting ligands can be attached to the albumin that can be recognized by specific cell receptors that are expressed on target cells or tissues. Expert opinion The particular advantages of albumin used in DDSs include ready availability, ease of chemical modification, good biocompatibility, and low immunogenicity. The regulatory approvals that have been received for several albumin-based therapeutic agents suggest that this approach will continue to be successfully explored.

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Section: Albumin Conjugates For Drug Deliverymentioning

confidence: 99%

Section: Expert Opinionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Albumin nanostructures as advanced drug delivery systems

Karimi

Bahrami

Ravari

et al. 2016

Expert Opinion on Drug Delivery

307

190

View full text Add to dashboard Cite

show abstract

“…[119] Other strategies, such as targeting albumin NPs (e.g., Abraxane) to matricellular proteins, have also been used to enhance the efficacy of cancer treatment. [120] NPs can also indirectly remodel the ECM via tumor-endothelial cell siRNA encapsulated lipid NPs. [121] In addition, NPs can be loaded with enzymes to degrade the ECM of tumors.…”

Section: Breaking Transport Barriers To Enhance Cancer Immunotheramentioning

confidence: 99%

Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells

Shen¹,

Hoang²,

Burchfield³

et al. 2017

Seminars in Immunology

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“…45 Of note, already HSA NPs has been used increasingly as delivery system because of their ability to bind to various drug molecules, great stability during storage, no toxicity and antigenicity, and biodegradability. [48][49][50][51] Bunschoten and co-workers also used HSA-based NPs formed non-covalent self assembled complexes with indocyanine green (ICG) dyes toward tumor draining lymph nodes for imaging. 52 Inspired by this strategy, through the synthesis of albumin nanoparticle via novel approaches such as self assembly, it could be possible to control the size of the nanoparticle in a way that can targeted TAAs directly toward the LN and improve the potency of cancer vaccines.…”

Section: Targeted Delivery To Peripheral Dcsmentioning

confidence: 99%

Multifunctional nanoparticles for cancer immunotherapy

Saleh

Shojaosadati

2016

Human Vaccines & Immunotherapeutics

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During the last decades significant progress has been made in the field of cancer immunotherapy. However, cancer vaccines have not been successful in clinical trials due to poor immunogenicity of antigen, limitations of safety associated with traditional systemic delivery as well as the complex regulation of the immune system in tumor microenvironment. In recent years, nanotechnology-based delivery systems have attracted great interest in the field of immunotherapy since they provide new opportunities to fight the cancer. In particular, for delivery of cancer vaccines, multifunctional nanoparticles present many advantages such as targeted delivery to immune cells, co-delivery of therapeutic agents, reduced adverse outcomes, blocked immune checkpoint molecules, and amplify immune activation via the use of stimuli-responsive or immunostimulatory materials. In this review article, we highlight recent progress and future promise of multifunctional nanoparticles that have been applied to enhance the efficiency of cancer vaccines.

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Efficient Delivery of Therapeutic Agents by Using Targeted Albumin Nanoparticles

Cited by 52 publications

References 88 publications

Albumin nanostructures as advanced drug delivery systems

Albumin nanostructures as advanced drug delivery systems

Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells

Multifunctional nanoparticles for cancer immunotherapy

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