Efficient delivery of hydrophobic drug, Cabazitaxel, using Nanodisc: A nano sized free standing planar lipid bilayer

Pandey, Abhishek; Piplani, Niyati; Mondal, Titas; Katranidis, Alexandros; Bhattacharya, Jaydeep

doi:10.1016/j.molliq.2021.116690

Cited by 7 publications

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…G 2 /M arrest is a mechanism widely exploited by the pharmaceutical industry to prevent cell division. The literature shows its application and efficiency in 3D model of prostate cancer (axitinib) [69], lung cancer (cabazitaxel) [70], colorectal cancer (docetaxel) [71], and breast cancer (epirubicin and hyaluronidase) [72,73]. A similar effect was observed in treatments with rucaparib in PC3 and LNCaP (prostate cancer) cell lines, delaying spheroid growth by increasing the rate of cell death [74].…”

Section: Drugs That Target the Cell Cycle In A Three-dimensional Cell...mentioning

confidence: 78%

Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in Cancer

Garnique,

Parducci,

de Miranda

et al. 2024

DDC

View full text Add to dashboard Cite

The monolayer (two-dimensional or 2D) cell culture, while widely used, lacks fidelity in replicating vital cell interactions seen in vivo, leading to a shift toward three-dimensional (3D) models. Although monolayers offer simplicity and cost-effectiveness, spheroids mimic cellular environments better. This is due to its nutrient gradients, which influence drug penetration and provide a more accurate reflection of clinical scenarios than monolayers. Consequently, 3D models are crucial in drug development, especially for anti-cancer therapeutics, enabling the screening of cell cycle inhibitors and combination therapies vital for heterogeneous tumor populations. Inhibiting processes like migration and invasion often require drugs targeting the cytoskeleton, which can exhibit dual functionality with cell cycle inhibitors. Therapeutic approaches with promising anti-cancer potential often exhibit reduced efficacy in 3D cell culture compared to their performance in monolayer settings, primarily due to the heightened complexity inherent in this system. In the face of this scenario, this review aims to survey existing knowledge on compounds utilized in both 2D and 3D cell cultures, assessing their responses across different culture types and discerning the implications for drug screening, particularly those impacting the cell cycle and cytoskeletal dynamics.

show abstract

Section: Drugs That Target the Cell Cycle In A Three-dimensional Cell...mentioning

confidence: 78%

Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in Cancer

Garnique,

Parducci,

de Miranda

et al. 2024

DDC

View full text Add to dashboard Cite

show abstract

Phospholipid-based nano drug delivery system of curcumin using MSP1D1 protein and poloxamer 407: a comparative study for targeted drug delivery to the brain

Shariare,

Mannan,

Khan

et al. 2024

J Nanopart Res

View full text Add to dashboard Cite

Styrene maleic acid lipid particles: Characterization using indicators and dyes as tools

Laguta,

Ronco-Campaña,

Goddard

2024

Journal of Molecular Liquids

View full text Add to dashboard Cite

Efficient delivery of hydrophobic drug, Cabazitaxel, using Nanodisc: A nano sized free standing planar lipid bilayer

Cited by 7 publications

References 56 publications

Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in Cancer

Two-Dimensional and Spheroid-Based Three-Dimensional Cell Culture Systems: Implications for Drug Discovery in Cancer

Phospholipid-based nano drug delivery system of curcumin using MSP1D1 protein and poloxamer 407: a comparative study for targeted drug delivery to the brain

Styrene maleic acid lipid particles: Characterization using indicators and dyes as tools

Contact Info

Product

Resources

About