Efficient Delivery of Antiapoptotic Signals from Marrow Stromal Cells to Acute Lymphoblastic Leukemia Cells Is Associated with Differential Expression of Genes Related to the Membrane and to Regulation of Apoptosis and Is Dependent in Part on Gap Junction Function
Abstract:Nonmalignant marrow stroma provides a favorable microenvironment for leukemia cell survival. The mechanisms of support are not well understood. Some studies have identified roles for some stromal derived molecules including some growth factors (EGF, FGF, PDGF), adhesion molecules (VCAM, selectins, osteopontins, integrins, fibronectin), cytokines (IL3, IL6, IL7) and others (KITLG, ANGPT1, CXCL12, LGALS3). It is clearly a multifactorial mechanism. We have developed a simple but powerful experimental system of hu… Show more
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