Efficient biocatalytic synthesis of green plasticizer 2,5-furanediformate isooctyl ester using an immobilized lipase

Abstract

2,5-furanediformate Isooctyl is a potential new green biobased plasticizer. At present, most of the preparation methods of are chemical methods, which not only have many by-products and are difficult to separate, but also cause environmental pollution. In this paper, the immobilized lipase Novozym435 was used as the catalyst to catalyze the transesterification of 2,5-furanediformate dimethyl ester and isooctyl alcohol to prepare 2,5-furanediformate Isoocty in organic medium, and the reaction process was optimized. The optimal process conditions were determined by single factor experiment: in 10 mL toluene system, the addition amount of immobilized lipase Novozym435 was 0.02 g, the molar ratio of 2,5-furanediformate dimethyl ester (1mmol) and isooctyl alcohol was 1:4, and 1 g 4Å molecular sieve was added to the reaction system, the reaction temperature was 50 °C, the reaction time was 24 hours, and the conversion rate of 2,5-furanediformate Isoocty was 89.63%.