“…[44][45][46][47] For instance, 2-amino-4-aryl(or heteroaryl)-7,7dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles bearing nitrile substituents show remarkable performance in the treatment of psoriatic arthritis, rheumatoid arthritis, and cancer therapy. [48][49][50] Moreover, these heterocyclic scaffolds also serve as photoactive materials and building blocks of natural products. 51,52 In consideration of the substantial importance of these bioactive motifs, a variety of catalysts including silica, 53 metal oxide nanoparticles, 54 Cu(II) oxymetasilicate, 55 Ca-MCM, 56 and silica bonded S-sulfonic acid 57 have been reported so far.…”