Efficient and Novel Method for Thiocyanation of Aromatic Compounds Using Trichloroisocyanuric Acid/Ammonium Thiocyanate/Wet SiO₂

Determination of the promoting effect of nano SiO2and H3PO4@nano SiO2in the thiocyanation ofN-containing aromatic compounds under solvent-free conditions

“…Nitrogen occurs in all living organisms, primarily in amino acids and thus in proteins and in the nucleic acids (DNA and RNA). [5] Several methods have been explored for the thiocyanation of (hetero)aromatic systems using various reagents such as oxone/NH 4 SCN, [6] N-thiocyanosuccinimde, [7] FeCl 3 /NH 4 SCN, [8] cerric ammonium nitrate (CAN)/NH 4 SCN, [9] montmorillonite K-10 clay/NH 4 SCN, [10] poly(4-diacetoxyiodo)styrene (PDAIS)/NH 4 SCN, [11] acidic Al 2 O 3 /NH 4 SCN, [12] HCl/H 2 O 2 /KSCN, [13] trichloroisocyanuric acid (TCCA)/NH 4 SCN/wet SiO 2 , [14] and citric acid/KSCN/H 2 O 2 . [15] Although the reported 2 K. Nikoofar and S. Gorji methods are efficient, some of them have disadvantages including low yields, strongly oxidizing conditions, long reaction times, high temperatures and use of expensive and toxic reagent or solvent.…”

Selectfluor-initiated cyanation of disulfides to thiocyanates

“…Much effort has been made toward the synthesis of thiocyanates so far. Generally, thiocyanates can be synthesized via the following two major routes (Scheme 1(a)): (1) thiocyanation of organic partners (arenes, organic halides, diazonium salts, and arylboronic acids) in the presence of inorganic thiocyanates 10–15 and (2) cyanation of organosulfur compounds including thiols, disulfides, and sulfinates with electrophilic and nucleophilic cyanation reagents. 16–20 Thiocyanates can also be prepared via CuCN-mediated direct aerobic oxidative cyanation of thiophenols and diaryl disulfides.…”

Synthesis and characterization of Trichloroisocyanouric acid functionalized mesoporous silica nanocomposite (SBA/TCCA) for the Acylation of Indole

“…Recently, thiocyanation of aromatic * For correspondence compounds, mononitration and dinitration of phenols have been reported over TCCA/NH 4 SCN/ wet SiO 2 mixture. 10,11 However, based on the literature review, TCCA-functionalized SBA-15 via co-condensation method has not been reported for acylation of indole. Therefore, in the present investigation, our interest emerged to synthesize SBA/TCCA nanocomposites for the first time in the liquid phase acylation of indole.…”