Efficient and fast screening and separation based on computer aided screening and complex chromatography method for 5-lipoxygenase inhibitors from Poria cocos
Abstract:Poria cocos (Schw.) Wolf (P. cocos) is a traditional Chinese medicinal materia that medicine food homologyl. In this study, based on the β-Amyloid deposition hypothesis of AD, a fast and efficient methods that ultrafiltration-liquid chromatography-mass spectrometry (UF-LC-MS) and molecular docking were developed for the rapid screening and identification of anti-5-lipoxygenase (anti-5-LOX) enzyme active ingredient of P. cocos ethyl acetate extract. Continuous counter-current chromatography (CCC) combined with … Show more
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