Efficient and Facile Synthesis of Gold Nanorods with Finely Tunable Plasmonic Peaks from Visible to Near-IR Range

Abstract

Although gold nanorods (GNRs) have been prepared with a wide range of methods for their uses as novel diagnostic and therapeutic agents, the synthesis of monodispersed GNRs with high yields and size tunability still requires further improvements. We report on a simple one-pot method for preparing highly monodispersed GNRs using phenols (e.g., hydroquinone, 1,2,3-trihydroxybenzene, and 1,2,4-trihydroxybenzene) as the reducing agent and NaBH 4 as the initiating reactant. Finetuning of the LSPR peak position of phenols-reduced GNRs from 550 to 1150 nm is accomplished by regulating the silver ion concentrations. The size of GNRs produced via phenols reduction can also be controlled by changing the NaBH 4 concentration. By systematically optimizing the concentrations of the reagents involved in the one-pot synthesis of GNRs, the yield (in many cases exceeding 90%) is significantly higher than that prepared with the commonly used reductant (e.g., ascorbic acid). The improved efficiency and controllability cut down the cost and time involved in GNRs production.

Applications of Nanoparticles for Anticancer Drug Delivery: A Review

“…285 The size of GNRs produced via phenols reduction could also be controlled by changing the NaBH 4 concentration. By systematically optimizing the concentrations of the reagents involved in the one-pot synthesis of GNRs, the yield was significantly higher than that prepared with the commonly used reductant (e.g., ascorbic acid).…”

Recent Progresses of Fluorescent Gold Nanoclusters in Biomedical Applications

“…94,95 Encapsulation AuNCs into the liposome provides the formulation photosensitive property because AuNCs can vigorously absorb light and then efficiently convert optical energy into local heat, [96][97][98] leading to release the drug in a short time. In this system, dihydrolipoic acid (DHLA)-stabilized AuNCs with a small diameter of ∼2 nm are firstly synthesized using a supercritical CO 2 method, 99 and the conjugates display bright fluorescence in the near-infrared region and high colloidal stability in biological media, then the AuNCs and DOX are embedded in the internal aqueous cavity of the liposome to form the AuNCs/DOX dual-loaded liposome.…”

Laccase-Assisted Rapid Synthesis of Colloidal Gold Nanoparticles for the Catalytic Reduction of 4-Nitrophenol

“…4,[10][11][12][13][14][15] However, the synthesis procedures for GNPs usually either involve the use of hazardous chemicals or the requirement of rigorous conditions, such as elevated temperature.…”

“…[7][8][9][10] Various chemical and physical methods for the preparation of GNPs with controlled size and shape have been reported. 4,[10][11][12][13][14][15] However, the synthesis procedures for GNPs usually either involve the use of hazardous chemicals or the requirement of rigorous conditions, such as elevated temperature. 14,15 A method employing enzymes as a template for the biosynthesis of GNPs [16][17][18][19][20][21][22][23][24][25][26] has recently attracted increasing attention because of its simplicity 1,26 and requirement for non-toxic chemicals.…”