Efficient and Easy One‐Pot Synthesis of New 3,5‐Dioxo‐thiazolo[2,3‐a] pyrimidine‐6‐carbonitrile and 4,6‐Dioxo‐pyrimido[2,1‐b][1,3]thiazine‐7‐carbonitrile Derivatives

Abstract

An easy, fast, and cheap way for the synthesis of the new 3,5‐dioxo‐thiazolo[2,3‐a] pyrimidine‐6‐carbonitriles and 4,6‐dioxo‐pyrimido[2,1‐b][1,3]thiazine‐7‐carbonitriles using epoxides α‐functionalized.

Chemistry of 1,3-thiazin-4-ones and their derivatives, 1995 - mid-2018

“…151 . 155 It was proposed that the reaction began with regioselective attack by sulfur on the epoxide, followed by elimination of HCN, and finally intramolecular nucleophilic acyl substitution.…”

Synthesis, characterization of new α‐quinolin‐3‐yl‐α‐(aminoamides, aminoesters) and bi‐heterocyclic aromatic systems from gem‐dicyanoepoxides and their pharmacological activity as antioxidant and antifungal agents

“…In addition, naturally occurring oxiranes are associated with various industrial, mechanistic, and biological activities [14]. Moreover, the use of α-cyanooxiranes as intermediates in organic synthesis has been extensively investigated [15][16][17][18][19], and they proved to be versatile precursors in the synthesis of a large variety of compounds of pharmaceutical interest [20,21]. gem-Dicyanoepoxide coupled quinoline moiety might be envisioned as a key intermediate for the synthesis of new hybrid compounds of medicinal importance.…”