Efficient and Easily Recyclable Catalyst for the Alkylation Reaction of Phenol and <i>tert</i>-Butyl Alcohol

Zhang, Dejin; Sun, Shi‐Gang; Wu, Qi; Xie, Yong; Liu, Chengcheng; Zhang, Keying; Shi, Hongwei; Xin, Zhuo; Wang, Hongyan

doi:10.1021/acsomega.2c04176

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…The efficient synthesis of 2-tert-butyl-4-methylphenol (2-TBM) is an important reaction, because of its great application in the preparation of many kinds of fine chemicals, additives in the food industry, UV absorbers, and polymerization inhibitors [1][2][3][4]. Isobutylene, chlorhydrocarbon, tert-butyl methyl ether, and tert-butyl alcohol were employed as alkylating agents for the preparation of 2-TBM, and many synthesis methods were developed; however, the alkylation of p-cresol and tert-butyl alcohol to synthesize 2-TBM has been proved to be the most effective way because of the convenient operation in the reaction process.…”

Section: Introductionmentioning

confidence: 99%

An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol

Zhang

Sun

et al. 2023

Catalysts

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The synthesis 2-tert-butyl-4-methylphenol is of great significance because of its wide application in industry, and the development of a highly efficient catalyst is necessary for the alkylation of p-cresol and tert-butyl alcohol. Here, an efficient and mild method was established. Caprolactam was chosen as the hydrogen-bonding acceptor; p-toluenesulfonic acid was employed as the hydrogen-bonding donor, and a deep eutectic solvent (DES) was prepared to catalyze the alkylation reaction. The structure of the deep eutectic solvent catalyst was characterized by 1H NMR spectra, thermogravimetric analysis, and Fourier transform infrared spectra (FT-IR). In addition, response surface design based on the Box–Behnken method was employed to optimize the alkylation reaction process parameters, and the study of reaction kinetics was also carried out subsequently. The recycle performance of the catalyst was evaluated by recovery experiments, and a good result was obtained. By drawing comparisons with the literature reported, we provide a mild method for the synthesis of 2-tert-butyl-4-methylphenol.

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Section: Introductionmentioning

confidence: 99%

An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol

Zhang

Sun

et al. 2023

Catalysts

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Effect of Vanadium on Phosphomolybdic acid structure and Catalytic evaluation of Solvent-free synthesis of 4-tert-butylphenol

Viswanadham

Jonnalagadda

2023

Journal of the Indian Chemical Society

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An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol

Wu¹,

Zhang²,

Sun³

et al. 2023

Preprint

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The synthesis 2-tert-butyl-4-methylphenol is of great significance because of its widely application in industry, and the development of highly efficient catalyst is necessary to the alkylation of p-cresol and tert-butyl alcohol. Here, an efficient and mild method was established, caprolactam was chosen as hydrogen-bonding acceptor, p-toluenesulfonic acid was employed as hydrogen-bonding donor, and deep eutectic solvent (DES) was prepared to catalyze the alkylation reaction. The structure of the DES catalyst was characterized by 1H NMR spectra, thermogravimetric analysis and fourier transform infrared spectra (FT-IR). In addition, response surface design based on Box-Behnken method was employed to optimize the alkylation reaction process parameters, the study of reaction kinetics was also carried out subsequently. The recycle performance of the catalyst was evaluated by recovery experiments, and a good result was obtained. Comparing with the literature reported, we here provide a mild method to the synthesis of 2-tert-butyl-4-methylphenol.

show abstract

Efficient and Easily Recyclable Catalyst for the Alkylation Reaction of Phenol and tert-Butyl Alcohol

Cited by 3 publications

References 42 publications

An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol

An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol

Effect of Vanadium on Phosphomolybdic acid structure and Catalytic evaluation of Solvent-free synthesis of 4-tert-butylphenol

An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol

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