Efficient analysis of pharmaceutical drug substances and products using a solid-state NMR CryoProbe

Abstract

Solid-state nuclear magnetic resonance (ssNMR) is a high-resolution and versatile spectroscopic tool for characterizing pharmaceutical solids. However, the inherent low sensitivity of NMR remains a significant challenge in the analysis...

Elucidations of Structure and Molecular Dynamics of Complex Polymers by State-of-the-Art Solid-State NMR Spectroscopy

“…Besides, the cryogenically cooled probes, which can reduce the electrical thermal noise by immersing the major electronic components in liquid nitrogen or helium, have been widely used in solution-state NMR for S/N ratio enhancement for several decades . However, the use of a cryoprobe in ssNMR is only commercially available recently, leading to more than 3-fold sensitivity enhancement. , In further combination with paramagnetic doping, nonuniform sampling, covariance processing, automated projection spectroscopy, etc., it is even possible to obtain a 4D, 5D, or even higher dimensional ssNMR spectrum within a couple of days . All those sensitivity-enhanced and time-saving ssNMR approaches have provided great potentials for tackling challenging problems in polymer science.…”

“…73 However, the use of a cryoprobe in ssNMR is only commercially available recently, leading to more than 3-fold sensitivity enhancement. 15,74 In further combination with paramagnetic doping, 75 nonuniform sampling, 76 covariance processing, 77 automated projection spectroscopy, 78 etc., it is even possible to obtain a 4D, 5D, or even higher dimensional ssNMR spectrum within a couple of days. 79 All those sensitivity-enhanced and time-saving ssNMR approaches have provided great potentials for tackling challenging problems in polymer science.…”