Efficiency of iodine supplementation, as potassium iodide, during lactation: A study in neonates and their mothers

González‐Iglesias, Héctor; Remy, Rafael R. de la Flor St.; López-Sastre, José; Fernández-Colomer, Belén; Ibáñez-Fernández, A.; Solı́s, Gonzalo; Sanz‐Medel, Alfredo; Sánchez, Marı́a Luisa Fernández

doi:10.1016/j.foodchem.2012.01.104

Cited by 10 publications

(13 citation statements)

References 13 publications

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“…Iodine in human milk responds quickly to dietary iodine intake, either supplemented [12] or consumed in natural foods, absorbed by the maternal thyroid and mammary glands through the Na(+)/I(-) symporter system [14]. In this regard, we have found that KI supplements are as effective as multivitamins to reach adequate UIC.…”

Section: Discussionmentioning

confidence: 83%

“…Our group has previously studied the effect of iodine supplementation in pregnant women on infant neurodevelopment [10] , and also studied the role of iodine as antioxidant agent present in human milk [11] . Iodine supplementation during lactation appears to be safe for mothers and neonates and provides an appropriate iodine intake [12], but most of its effects on human milk composition are unknown. In the given context, the aims of the present study are (a) to compare the effect of potassium iodine (KI) supplements and multivitamins on the levels of different bioactive factors potentially involved in neural growth (BDNF, GDNF, GFAP, LPA, ATX), metabolic regulation (leptin, adiponectin, FGF21), and oxidative balance (SOD and GSH-Px activities), (b) to assess significant differences between colostrum and mature milk with regard to all these components, and (c) to explore possible interrelationships between neurotrophic factors, metabolic regulators and/or antioxidants present in human milk.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Components in Human Milk Along the First Month of Life: Effects of Iodine Supplementation during Pregnancy

et al. 2016

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Background/Aims: Human milk is considered the most suitable food for infants. The potential benefits of breastfeeding can be explained by the presence of different growth and neurotrophic factors in human milk. This study was designed to detect some biomarkers in human milk, which could be involved in the infant neurodevelopment and in the regulation of the maturation of neonatal intestine (brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), glial fibrillary acidic protein (GFAP), fibroblast growth factor 21 (FGF21), lysophosphatidic acid (LPA) and autotaxin (ATX)), and compare them on the basis of the consumption of iodine supplements or multivitamins. Methods: A prospective study included 37 healthy breastfeeding mothers, divided into 3 different groups: (1) 10 mothers who did not take supplements, (2) 17 mothers who took potassium iodine (KI) 200 µg/day and (3) 10 mothers who took a multivitamin supplement. Results: The concentrations of BDNF, GDNF, GFAP, FGF21, LPA and ATX in human milk were not significantly different in women who took a multivitamin or KI supplement compared with those who did not take any supplement. Conclusions: The presence of neurotrophic factors in human milk is neither modified by the consumption of supplements nor by their type.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Bioactive Components in Human Milk Along the First Month of Life: Effects of Iodine Supplementation during Pregnancy

et al. 2016

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“…It is known that low intakes of these micronutrients are of significant clinical relevance in pregnant women because they can lead to health problems in the mother and foetus/newborn [6,28,35]. Also during lactation, there is an increased need for some micronutrients (e.g., iodine and iron) [36,37]. Of critical concern are the high needs of folic acid and iodine before and during pregnancy which generally are not provided by a well-balanced diet alone [17].…”

Section: Nutrient Supply and Early Programmingmentioning

confidence: 99%

Impact of Micronutrient Status during Pregnancy on Early Nutrition Programming

et al. 2019

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Background: Nutrition status prior to conception and during pregnancy and infancy seems to have an influence on the disease risk in adulthood (early nutrition/developmental programming). We aimed to review the current knowledge on the role of micronutrients in early nutrition programming and its implications for healthcare. Summary of Findings: Globally and even in high-income countries where a balanced diet is generally accessible, an inadequate maternal micronutrient status is common. This may induce health problems in the mother and foetus/newborn both immediately and in later life. Pregnant women and those who may become pregnant should aim to achieve a satisfactory micronutrient status from a well-balanced diet, and where necessary from additional supplements. Key Messages: We emphasise the need for a call to action for healthcare providers and policymakers to better educate women of child-bearing age regarding the short- and long-term benefits of an appropriate micronutrient status. The role of micronutrient status in early nutrition programming needs to be emphasized more to address the still limited awareness of the potential long-term health repercussions of suboptimal micronutrient supply during pregnancy.

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“…In the human body, it is essential for the production of triiodothyronine (T 3 ) and thyroxine (T 4 ) hormones which are responsible to regulate body temperature and metabolic rate in adults and children and thus for the proper functioning and the development of the human body [1]. Iodine also helps in the maturation of the central nervous system, and the development of foetal and early postnatal life [2]. The most known adverse effect of iodine deficiency is goitre.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, various analytical methods have been used for the determination of trace amounts of iodine in different types of samples. These include inductively coupled plasma mass spectrometry (ICP-MS) [2,3,[11][12][13][14][15], radiochemical neutron activation analysis (RNAA) [9,16], ion chromatography (IC) [17][18][19][20][21], high performance liquid chromatography (HPLC) [22], HPLC with UV detection [4], HPLC-diode array detection [23], inductively coupled plasma-atomic emission spectrophotometry (ICP-AES) [24] and atomic absorption spectrophotometry (AAS) [25]. Most of the techniques mentioned above, except RNAA, are not selective, suffer from interferences and need pre-concentration or separation procedures which lead to the loss of iodine [1].…”

Section: Introductionmentioning

confidence: 99%

Determination of iodine content in Fijian foods using spectrophotometric kinetic method

Chandra

Maata

Prasad

2019

Microchemical Journal

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The spectrophotometric kinetic method was validated for the determination of iodine in different food samples. The method is based on the iodide catalysed reduction of Ce 4+ to Ce 3+ by As 3+. The absorbance of the kinetic indicator reaction was measured at 370 nm for exactly 1 min at 37°C. The change in absorbance per min, as a measure of initial rate, was plotted against the different iodine concentrations to achieve a linear calibration equation with the R 2 value of 0.9998 which showed excellent reproducibility. The limit of detection (LOD) was 1.54 ng/mL and the limit of quantification (LOQ) was 4.90 ng/mL. The incineration of the food organic matter was achieved by ashing the food samples at 600°C using KOH and ZnSO 4 in steps for 3 h. Trace levels of iodine (ng) were determined successfully using the validated spectrophotometric kinetic method for the 9 food samples (36 sub-samples). The Fiji seaweeds, lumiwawa (brown seaweed) showed the highest iodine content being 6373.30 ± 0.39 ng/g followed by sea grapes (green seaweed) 1162.81 ± 0.61 ng/g, lettuce 114.81 ± 0.08 ng/g, English cabbage 108.40 ± 0.06 ng/g, Chinese cabbage 104.01 ± 0.06 ng/g, pumpkin 101.24 ± 0.08 ng/g, long bean 97.61 ± 0.10 ng/g, banana 76.18 ± 0.10 ng/g and tomato 40.32 ± 0.04 ng/ g. The coefficient of variation for the sample analysis was < 5.31% with a mean and standard deviation of 2.55 ± 0.17% for the food samples analysed. The recovery analysis of iodine from standard samples ranged from 99.84 ± 0.91% to 100.24 ± 5.92% with an excellent average recovery of 100.06 ± 3.16%. The analytical coefficient of variation was calculated to be 0.34% for the food samples analysed. This shows exceptional system analytical stability of the method used in this study.

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Efficiency of iodine supplementation, as potassium iodide, during lactation: A study in neonates and their mothers

Cited by 10 publications

References 13 publications

Bioactive Components in Human Milk Along the First Month of Life: Effects of Iodine Supplementation during Pregnancy

Bioactive Components in Human Milk Along the First Month of Life: Effects of Iodine Supplementation during Pregnancy

Impact of Micronutrient Status during Pregnancy on Early Nutrition Programming

Determination of iodine content in Fijian foods using spectrophotometric kinetic method

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