Efficiency of Immunocorrection in Сhronic Viral Hepatitis C Patients Treated by Antivirals

Abstract

Abstract. Chronic hepatitis C antiviral therapy should be followed by immune rehabilitation measures directed to T-cell immunity stimulation and elimination of circulating immune complexes. The dynamics of concentrations of molecular fractions of circulating immune complexes and immunoglobulins has been studied. Moreover, phagocytosis indices were evaluated during combined antiviral therapy by standard PEG-interferon and ribavirin and immuno correction drag Ronkoleukin. Application of Ronkoleukin in combination with antiviral therapy determines possibilities to optimize existing treatment protocols of chronic hepatitis C.

Improvement of the Effectiveness of Antiviral Treatment of Patients with Chronic Hepatitis C and Concomitant Diabetes Mellitus Type II using Alpha-Lipoic Acid and Lactulose

“…Peculiarities of CHC course depend on immunopathological reactions [4,6,9]. However, unfortunately the immune system in the majority of patients with CHC is unable to eliminate the virus allowing it to replicate in hepatocytes for a long time [7,20].…”

“…The majority of domestic and foreign authors studying basic pathogenic mechanisms of disorders in CHC have noted with significant difference the decrease in the concentration of pro-inflammatory cytokines in contrast to their increase in case of normal functioning of the immune system and simultaneous increase in the content of anti-inflammatory cytokines. High level of IL-4 in case of decrease in IL-2 level in blood serum was studied to be asso-ciated with long-term persistence of HCV in the body, high activity of infectious process [9,10]. In addition, according to many researchers' data the crucial role in the pathogenesis of many structural and functional disorders in patients with DM (hepatopathy, insulin resistance, vessel wall disorders) belongs to cytokine system imbalance [16].…”