Efficiency of High Magnetic Fields in Solid-state NMR

Hashi, Kenjiro; Deguchi, K.; Yamazaki, Toshio; Ohki, Shinobu; Matsumoto, Shinji; Nishijima, G.; Goto, Atsushi; Yamada, Kazuhiko; Noguchi, Takashi; Sakai, S.; Takahashi, Masato; Yanagisawa, Yoshinori; Iguchi, Seiya; Maeda, Hideaki; Tanaka, Ryoji; Nemoto, Takahiro; Suematsu, H.; To, Janet; Torres, Jaume; Pervushin, Konstantin; Shimizu, Tadashi

doi:10.1246/cl.151063

Cited by 11 publications

(7 citation statements)

References 10 publications

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“…Figure 5 compares a 2D 13 C NMR solid-state spectrum for a protein sample (polycrystalline aquaporin) obtained with a persistent-mode 700 MHz (16.4 T) LTS NMR magnet (figure 5(a)) and that with the driven-mode 1.02 GHz LTS/Bi-2223 NMR magnet (figure 5(b)) [40]. The NMR pulse sequence was dipolar-assisted rotational resonance, determining the distance between atoms.…”

Section: Nmr Spectramentioning

confidence: 99%

Review of recent developments in ultra-high field (UHF) NMR magnets in the Asia region

Yanagisawa

Hamada²,

Hashi

et al. 2022

Supercond. Sci. Technol.

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This paper reviews recent developments in ultra-high field (UHF) superconducting magnets for nuclear magnetic resonance (NMR) in the Asia region, in particular those for high-resolution NMR magnets using high-temperature superconductor (HTS) coils. In Japan, a power supply driven-mode 1.02 GHz (24.0 T) NMR magnet using a Bi-2223 inner coil was developed in 2015, providing the first high-resolution NMR at a 1H NMR frequency of >1 GHz (23.5 T). In late 2017, a new project started for developing a persistent-mode 1.3 GHz (30.5 T) NMR magnet comprising a REBCO inner coil, a Bi-2223 middle coil, and a low-temperature superconductor (LTS) outer coil. The magnet employs the newly developed state-of-the-art superconducting joints between HTSs necessary for the persistent-mode operation, as well as magnet technologies providing an ultra-high magnetic field of >30.5 T with high temporal stability and spatiality homogeneity for high-resolution NMR measurement. In China, a ~20 mm-cold bored magnet comprising an LTS outer coil and no-insulation (NI) REBCO inner coils was developed and recorded a field of 32.35 T, the highest magnetic field ever achieved with an all-superconducting magnet, which can be used as a small cold-bored NMR. In Korea, a liquid helium-free 400 MHz (9.39 T) all REBCO NMR magnets using NI winding was developed, which is operational. These technologies provide future perspective for a UHF NMR magnet with key features of persistent-mode operation, an operating field of 1.4 GHz using (32.9 T)-class magnets, and the liquid helium-free operation.

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Section: Nmr Spectramentioning

confidence: 99%

Review of recent developments in ultra-high field (UHF) NMR magnets in the Asia region

Yanagisawa

Hamada²,

Hashi

et al. 2022

Supercond. Sci. Technol.

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“…The magnet reached 1020 GHz in 2015 using a Bi-2223 inner HTS coil with outer NbTi and Nb 3 Sn LTS coils. With this magnet, they have demonstrated the ability to acquire high-quality natural abundance spectra for insensitive nuclei such as 17 O (0.04% natural abundance (1, 23)). 1 H- 1 H- 1 H 3D data indicate the field homogeneity and stability achieved at 24 T (24).…”

Section: Perspectivementioning

confidence: 99%

“…However, there are many additional NMR active nuclei with critical roles in biology for which work has been limited to date due to sensitivity- and resolution-related challenges, such as 35/37 Cl and 23 Na. The group at NIMS in Japan has demonstrated measurements at 24 T on the spin 3/2 nuclei 35 Cl and 37 Cl (44, 45), as well as 17 O (1, 23). One of the fields with greatest potential for growth with the advent of magnetic fields over 1GHz is 17 O NMR (39, 46), a critical element in biology which could serve as an exquisite probe for a variety of mechanistic and structural questions, including enzyme catalysis, pharmaceuticals analysis, protein structure and hydration (47, 48), as well as materials/MOF applications mentioned above.…”

Section: Perspectivementioning

confidence: 99%

NMR of Macromolecular Assemblies and Machines at 1 GHz and Beyond: New Transformative Opportunities for Molecular Structural Biology

Quinn

Wang

Polenova

2017

Methods in Molecular Biology

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“…Although the generated magnetic field exhibited ripples and drifts over time depending on the performance of the power supply, they demonstrated the possibility of stabilizing the magnetic field using a highly stable current supply and a field-frequency lock system [21]. Subsequently, Hashi et al succeeded in developing a 24 T (1.02 GHz) driven mode NMR magnet and acquired NMR spectra of biological samples [22,23]. Furthermore, MIT is developing a 30.5 T (1.3 GHz) driven mode NMR magnet [24].…”

Section: Introductionmentioning

confidence: 99%

Review of the temporal stability of the magnetic field for ultra-high field superconducting magnets with a particular focus on superconducting joints between HTS conductors

Takeda¹,

Maeda²,

Ohki³

et al. 2022

Supercond. Sci. Technol.

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Superconducting magnets used in applications such as magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) require significant temporal magnetic field stability, which can be achieved when the MRI and NMR magnets are operated in the persistent current mode (persistent-mode) using superconducting joints. However, the ultra-high field MRI and NMR magnets are sometimes operated in the driven mode. Herein, we present an analysis of the temporal magnetic field drift and fluctuations observed for MRI and NMR magnets operating in the driven mode and an exploration of effective methods for stabilizing the temporal magnetic field fluctuations. In the last decade, substantial improvements have been achieved in superconducting joints between high-temperature superconductors (HTS). These superconducting joints enable the development of persistent-mode ultra-high field magnets using HTS coils. Therefore, we herein review the superconducting joint technology for HTS conductors and describe the results of the persistent-mode operation achieved by a medium-field NMR magnet using an HTS coil. Particularly, the cutting-edge progress achieved concerning HTS superconducting joints, including joining methods, superconducting properties, and future prospects, is highlighted along with the issues that need to be addressed.

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Efficiency of High Magnetic Fields in Solid-state NMR

Cited by 11 publications

References 10 publications

Review of recent developments in ultra-high field (UHF) NMR magnets in the Asia region

Review of recent developments in ultra-high field (UHF) NMR magnets in the Asia region

NMR of Macromolecular Assemblies and Machines at 1 GHz and Beyond: New Transformative Opportunities for Molecular Structural Biology

Review of the temporal stability of the magnetic field for ultra-high field superconducting magnets with a particular focus on superconducting joints between HTS conductors

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