Efficiency evaluation of a bivalent vaccine in the prophylaxis of mastitis in cows

Abstract

Mastitis in cows represents one of the most actual problems in intensive dairy production. The longtime different approaches to the treatment of mastitis have not offered a suitable solution, and the problem of mastitis is still present and acute. Prevention of pathogen penetration into the mammary gland, its colonization and multiplication impose a constant need for regular inspections of milk, as well as preventive and therapeutic measures to reduce the incidence of mastitis. Studies in the field of vaccination of ruminants against mastitis pathogens suggest a limited success in obtaining significant results in immunoprophylaxis. Considering the results of other researchers and our own research, and bearing in mind the problems mastitis caused by Staphylococcus aureus and Streptococcus agalactiae represent, the aim of this study was the preparation and testing of an indigenous vaccine prepared with two stable strains, SAU 7 (S. aureus) and SAG 3 (Str.agalactiae). The dose was 5 mL/cow and consisted of inactivated bacterial S. aureus SAU 7 cells in a concentration of 1x10 10 cfu/mL and Str. agalactiae SAG 3 in a concentration of 4 x 10 9 cfu/mL. The number of somatic cells in the milk samples during the whole study period was higher in vaccinated cows in both groups compared with the control, but this difference was not statistically significant. The concentration of immunoglobulin IgG in the milk of vaccinated cows was significantly higher than the concentration of this class of proteins in the milk of unvaccinated cows.

Mastitis vaccines in dairy cows: Recent developments and recommendations of application

“…The efficacy of a polyvalent herd-specific autovaccine containing S. aureus strain SAU 7 and S. agalactiae strain SAG 3 was evaluated [ 20 ]. The IgG response in the milk of vaccinated cows was significantly higher than in the milk of unvaccinated cows [ 20 ].…”

Mastitis challenges in Serbian dairy farming: a study on somatic cell counts and pathogen distribution

“…Mastitis significantly affects dairy herds, leading to economic losses due to high treatment costs, reduced milk production and quality, increased labor and premature culling (Magaš et al, 2013;Benić et al, 2018;Poljak et al, 2022). It also raises concerns about antimicrobial use, leading to resistant strains and antimicrobial residues in dairy products, posing public health risk (Turk et al, 2017).…”

Detection of Several Virulence Properties, Antibiotic Resistance and Phylogenetic Relationship in E. Coli Isolates Originated from Cow Mastitis

“…Mastitis reduces milk yield, increases health cost and makes milk less suitable for both consumption and processing [1]. Pathogenic microorganisms that most frequently cause mastitis can be divided into two groups based on their source: environmental and contagious.…”