Efficiency and Mechanism of the Antioxidant Action of trans-Resveratrol and Its Analogues in the Radical Liposome Oxidation

Stojanović, Sandra; Sprinz, H.; Brede, O.

doi:10.1006/abbi.2001.2388

Cited by 241 publications

(156 citation statements)

References 36 publications

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“…and can enhance the activity of vitamin C when used together (45). We speculate that the effect of resveratrol on HIF-1␣ degradation could possibly result from its interference with HIF-prolyl hydroxylase activity, which requires additional investigation.…”

Section: Discussionmentioning

confidence: 95%

trans- 3,4,5′-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

Cao

Fang

Xia

et al. 2004

Clinical Cancer Research

168

132

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ABSTRACTtrans-3,4,5-Trihydroxystibene (resveratrol) is a natural product commonly found in the human diet and has been shown recently to have anticancer effects on various human cancer cells. However, the molecular basis for its anticancer action remains to be elucidated. In this study, we investigated the effect of resveratrol on hypoxia-inducible factor 1␣ (HIF-1␣) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells A2780/CP70 and OVCAR-3. We found that although resveratrol did not affect HIF-1␣ mRNA levels, it did dramatically inhibit both basal-level and growth factor-induced HIF-1␣ protein expression in the cells. Resveratrol also greatly inhibited VEGF expression. Mechanistically, we demonstrated that resveratrol inhibited HIF-1␣ and VEGF expression through multiple mechanisms. First, resveratrol inhibited AKT and mitogen-activated protein kinase activation, which played a partial role in the down-regulation of HIF-1␣ expression. Second, resveratrol inhibited insulin-like growth factor 1-induced HIF-1␣ expression through the inhibition of protein translational regulators, including M r 70,000 ribosomal protein S6 kinase 1, S6 ribosomal protein, eukaryotic initiation factor 4E-binding protein 1, and eukaryotic initiation factor 4E. Finally, we showed that resveratrol substantially induced HIF-1␣ protein degradation through the proteasome pathway. Our data suggested that resveratrol may inhibit human ovarian cancer progression and angiogenesis by inhibiting HIF-1␣ and VEGF expression and thus provide a novel potential mechanism for the anticancer action of resveratrol.

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Section: Discussionmentioning

confidence: 95%

trans- 3,4,5′-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

Cao

Fang

Xia

et al. 2004

Clinical Cancer Research

168

132

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“…They concluded that para-hydroxyl group plays greater role than the meta positioned hydroxyl groups. 139 Pulse radiolysis confirmed that para hydroxyl group is involved in the free radical scavenging function. Fang et al studied the antioxidant effect of trans-resveratrol and its analogue and reported that antioxidant activity is depend on the position of hydroxyl groups.…”

Section: Structure Activity Relationship Of Resveratrolmentioning

confidence: 93%

Resveratrol: A multitargeted agent for age-associated chronic diseases

Harikumar¹,

Aggarwal²

2008

Cell Cycle

481

339

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Extensive research within the last decade has revealed that most chronic illnesses such as cancer, cardiovascular and pulmonary diseases, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. Thus mono-targeted therapies developed for the last two decades for these diseases have proven to be unsafe, ineffective and expensive. Although fruits and vegetables are regarded to have therapeutic potential against chronic illnesses, neither their active component nor the mechanism of action is well understood. Resveratrol (trans-3, 5, 4'-trihydroxystilbene), a component of grapes, berries, peanuts and other traditional medicines, is one such polyphenol that has been shown to mediate its effects through modulation of many different pathways. This stilbene has been shown to bind to numerous cell-signaling molecules such as multi drug resistance protein, topoisomerase II, aromatase, DNA polymerase, estrogen receptors, tubulin and F1-ATPase. Resveratrol has also been shown to activate various transcription factor (e.g., NFκB, STAT3, HIF-1α, β-catenin and PPAR-γ), suppress the expression of antiapoptotic gene products (e.g., Bcl-2, Bcl-X L , XIAP and survivin), inhibit protein kinases (e.g., src, PI3K, JNK and AKT), induce antioxidant enzymes (e.g., catalase, superoxide dismutase and hemoxygenase-1), suppress the expression of inflammatory biomarkers (e.g., TNF, COX-2, iNOS and CRP), inhibit the expression of angiogenic and metastatic gene products (e.g., MMPs, VEGF, cathepsin D and ICAM-1), and modulate cell cycle regulatory genes (e.g., p53, Rb, PTEN, cyclins and CDKs). Numerous animal studies have demonstrated that this polyphenol holds promise against numerous age-associated diseases including cancer, diabetes, Alzheimer, cardiovascular and pulmonary diseases. In view of these studies, resveratrol's prospects for use in the clinics are rapidly accelerating. Efforts are also underway to improve its activity in vivo through structural modification and reformulation. Our review describes various targets of resveratrol and their therapeutic potential.

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“…[7][8][9][10] Hydroxystilbenes, naturally occurring polyphenolic compounds, have attracted significant attention because of their powerful free radical scavenging properties. [11][12][13] Resveratrol (trans-3Ј,4,5Ј-trihydroxystilbene), a representative of this group, has been widely investigated for its neuroprotective effects in various brain pathological models including experimental cerebral ischemia. 14,15) Resveratrol also has been reported to exert a potential neuroprotective property against Ab-induced toxicity in various neuronal cultures, which is mainly attributable to its antioxidant effect, suggesting its therapeutic potential in AD.…”

mentioning

confidence: 99%

Neuroprotective Effect of Oxyresveratrol from Smilacis Chinae Rhizome on Amyloid .BETA. Protein (25-35)-Induced Neurotoxicity in Cultured Rat Cortical Neurons

Ban

Jeon

Nguyen

et al. 2006

Biological & Pharmaceutical Bulletin

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Efficiency and Mechanism of the Antioxidant Action of trans-Resveratrol and Its Analogues in the Radical Liposome Oxidation

Cited by 241 publications

References 36 publications

trans- 3,4,5′-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

trans- 3,4,5′-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

Resveratrol: A multitargeted agent for age-associated chronic diseases

Neuroprotective Effect of Oxyresveratrol from Smilacis Chinae Rhizome on Amyloid .BETA. Protein (25-35)-Induced Neurotoxicity in Cultured Rat Cortical Neurons

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