The paper presents the analysis of the cooling of a photovoltaic (PV) panel integrated on the facade of buildings, in vertical position, for different orientations: South, SouthEast and SouthWest. The effect of the cooling of PV panel is presented comparatively for the basic case, the case of the PV location apparently on the building facade, without the possibility of ventilation on its rear area and also for the integration in the ventilated facade of the building. Finally, the optimal solutions for obtaining passive cooling by using air and heat sinks or active cooling by using water film exchanger are evaluated. The study aims to evaluate the efficiency of PV panels according to climatic conditions and does not concern the operation of the entire photovoltaic system.