Efficicient, high yield, oxidation of thiols and selenols to disulphides and diselenides

Synthesis of 13C6, 3H, and 14C labeled Sch 414319 and 35S labeling of an analog, Sch 225336

“…Aniline 5 was generated by the treatment of 4 with sodium azide and was subsequently converted to thiophenol 6 via diazonium salt formation followed by reaction with potassium ethyl xanthate 3 . Disulfide 7 was formed by the oxidation of thiophenol 6 using sodium perborate 4 . An impurity was present that co-eluted with the disulfide during column chromatography}the impure disulfide was used in the subsequent reaction and the impurity was removed at a later stage by column chromatography.…”

2-Pyrrolidinones and 3-Pyrrolin-2-ones: A Study on the Chemical Reactivity of These Structural Moieties

“…Thus, the treatment of 1 with a suspension of NaH in THF followed by reaction with (Boc) 2 O [3] generated a compound characterized by 1 H NMR as the pyrrolidinone 2. The substance 2 was partially converted to a product identified by 1 H NMR as the thiophenoxylactam 3, as result of alpha deprotonation of the carbamate of 2 with LDA solution [4], followed by nucleophilic substitution of the generated lithium enolate with diphenyl disulfide [5]. At the 1 H NMR spectrum of 3, signals were detected relative to two isomers in the proportion (10 : 1) measured by integrals relative to methyls of the groups tert-butoxycarbonyl at δ 1.52 (major isomer) and δ 1.43 (minor isomer).…”

Synthesis of Bi2WO6 nanoplates using oleic acid as a green capping agent and its application for thiols oxidation

“…A number of methods for this conversion, such as potassium dichromate [1], I 2 /HI [2], sodium perborate [3], and nitric oxide [4], have been used. Most of these procedures suffer from drawbacks, such as generation of undesirable waste materials, low selectivity, over-oxidation, and low yield.…”