Efficacy, tolerability, and kinetics of lamotrigine in infants

Influence of uridine diphosphate glucuronosyltransferase inducers and inhibitors on the plasma lamotrigine concentration in pediatric patients with refractory epilepsy

“…In the present study, the CD ratio of LTG was higher in infants aged 6e11 months regardless of concomitant use of VPA and/or inducers. Mikitai et al [23] evaluated the pharmacokinetics of LTG in 7 infants treated with inducers and reported that the mean clearance of LTG in infants aged 2 months was about 50% lower than that in infants aged 2e12 months. When managing infants with epilepsy, it seems likely that it is important to carefully titrate the dose of LTG.…”

Adjunctive lamotrigine for partial seizures in patients aged 1 to 24 months

“…In an openlabel study comparing the efficacy of lamotrigine in partial seizures in infants younger than 1 year with those aged 1 to 12 years, similar response ratios were observed in the two age groups (Ϫ0.67 Ϯ 0.49 in infants younger than 1 year and Ϫ0.68 Ϯ 0.38 in those aged 1 to 12 years). 12 In a double-blind, parallel-group trial in patients (n ϭ 199) aged 2 to 16 years whose partial seizures were uncontrolled with their current AED regimens, the percentage of patients with Ն50% reduction from baseline in the frequency of seizures over the 16-week treatment period was 42% with lamotrigine compared with 16% with placebo (p Ͻ 0.001) for all partial seizures. 8 The similarity of the current results to data from other young patient populations suggests that overestimation of the efficacy of study medication-a potential disadvantage of the responder-enriched design-did not operate in this study.…”

“…A small, open-label study of 13 patients younger than 1 year suggested that lamotrigine add-on therapy could be well tolerated and efficacious in infants with refractory partial seizures or infantile spasms. 12 The randomized, double-blind, placebo-controlled trial described herein was conducted to assess the efficacy and tolerability of adjunctive lamotrigine for the treatment of partial seizures in infants aged 1 to 24 months. METHODS Patients.…”

Newer Anticonvulsant Medications in Pediatric Neurology

“…In children, it is indicated as an adjunctive treatment for seizures associated with Lennox-Gastaut syndrome. Recent studies have shown that lamotrigine is well tolerated and efficacious as monotherapy and adjuvant therapy in patients as young as 1 month of age [14•,Class I;15]. Efficacy has been demonstrated in infantile spasms, juvenile myoclonic epilepsy, absence epilepsy, benign rolandic epilepsy, and Rett syndrome [7,16].…”