Efficacy, tissue distribution, and residue depletion of oxytetracycline in WS-RLP infected California red abalone Haliotis rufescens

Rosenblum, E. S.; Robbins, Thea T.; Scott, Benjamin B.; Nelson, Sidney D.; Juhasz, Christy I.; Craigmill, Arthur L.; Tjeerdema, Ronald S.; Moore, James D.; Friedman, Carolyn S.

doi:10.1016/j.aquaculture.2008.03.005

Cited by 14 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Abalone were maintained in recirculating seawater systems held at 14–15°C for 4 months to allow depletion of OTC to <50 ppm, a level shown to allow re-infection by the WS-RLO (Friedman et al, 2007; Rosenblum et al, 2008). OTC levels in the DG were analyzed according to Association of Official Analytical Chemists [AOAC] (1990) as modified by Friedman et al (2003, 2007).…”

Section: Methodsmentioning

confidence: 99%

“…The red abalone (~30–40 mm group) and all black abalone were medicated with oxytetracycline (OTC) at a dose of ~90 mg/kg weight for 3 days according to the methods of Friedman et al (2007) in order to allow the abalone to purge themselves of RLO infections ( Friedman et al, 2003 , 2007 ; Rosenblum et al, 2008 ). Abalone were maintained in recirculating seawater systems held at 14–15°C for 4 months to allow depletion of OTC to <50 ppm, a level shown to allow re-infection by the WS-RLO ( Friedman et al, 2007 ; Rosenblum et al, 2008 ). OTC levels in the DG were analyzed according to Association of Official Analytical Chemists [AOAC] (1990) as modified by Friedman et al (2003 , 2007 ).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Reduced disease in black abalone following mass mortality: phage therapy and natural selection

et al. 2014

View full text Add to dashboard Cite

Black abalone, Haliotis cracherodii, populations along the NE Pacific ocean have declined due to the rickettsial disease withering syndrome (WS). Natural recovery on San Nicolas Island (SNI) of Southern California suggested the development of resistance in island populations. Experimental challenges in one treatment demonstrated that progeny of disease-selected black abalone from SNI survived better than did those from naïve black abalone from Carmel Point in mainland coastal central California. Unexpectedly, the presence of a newly observed bacteriophage infecting the WS rickettsia (WS-RLO) had strong effects on the survival of infected abalone. Specifically, presence of phage-infected RLO (RLOv) reduced the host response to infection, RLO infection loads, and associated mortality. These data suggest that the black abalone: WS-RLO relationship is evolving through dual host mechanisms of resistance to RLO infection in the digestive gland via tolerance to infection in the primary target tissue (the post-esophagus) coupled with reduced pathogenicity of the WS-RLO by phage infection, which effectively reduces the infection load in the primary target tissue by half. Sea surface temperature patterns off southern California, associated with a recent hiatus in global-scale ocean warming, do not appear to be a sufficient explanation for survival patterns in SNI black abalone. These data highlight the potential for natural recovery of abalone populations over time and that further understanding of mechanisms governing host–parasite relationships will better enable us to manage declining populations.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Reduced disease in black abalone following mass mortality: phage therapy and natural selection

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Numerous studies have investigated the pharmacokinetics of OTC in aquatic animals (Grondel, Nouws, Schutte & Driessens 1989; Haug & Hals 2000; Rigos, Alexis, Andriopoulou & Nengas 2002; Chen, Getchell, Wooster, Craigmill & Bowser 2004; Rigos & Troisi 2005). While there are limited data published on OTC pharmacokinetics in crustaceans (Reed, Siewicki & Shah 2006; Poapolathep, Poapolathep, Jermnak, Imsilp, Wannapat, Sugita‐Konishi & Kumagai 2008; Rosenblum, Robbins, Scott, Nelson, Juhasz, Craigmill, Tjeerdema, Moore & Friedman 2008), there are no reports for E. sinensis . Additionally, to reduce the risk of exposure of consumers to antibiotic residues in edible tissues, farmers need advice on the withdrawal period needed when antibiotics have to be used in the culture.…”

Section: Introductionmentioning

confidence: 99%

Kinetic analysis of oxytetracycline residues in Chinese mitten crab, Eriocheir sinensis, muscle following intramuscular administration

Feng

Gao

et al. 2010

Journal of Fish Diseases

View full text Add to dashboard Cite

Crab culture is a very important economic industry in China. An epidemic of tremor disease of Chinese mitten crabs, Eriocheir sinensis, has become a serious problem in recent years. A spiroplasm has been proved to be the causative agent of this disease. Oxytetracycline (OTC) is used widely in aquaculture and was confirmed to be very effective against this pathogen. In this study, the distribution and depletion patterns of OTC in crab muscle were evaluated following single intramuscular doses of 2, 8 and 40 mg kg(-1) body weight. OTC was detected with a validated HPLC method. Concentration-time profiles were well described by a three-compartment model with first-order absorption after a single dose of 8 and 40 mg kg(-1). For comparison, a non-compartment model was employed. A withdrawal time of 48.29 and 55.92 days was suggested prior to consumption after receiving 8 and 40 mg kg(-1). A recommended therapeutic dose of OTC in theory was calculated to be 36.37 mg kg(-1). OTC was distributed well throughout the body. The elimination of OTC in muscle was slower compared with fish and other crustaceans. A dose of 40 mg kg(-1) is suggested for practical use.

show abstract

Histological features of Rickettsia-like organisms in the European flat oyster (Ostrea edulis L.)

Tinelli

Santacroce

Passantino

et al. 2019

Environ Sci Pollut Res

View full text Add to dashboard Cite

Efficacy, tissue distribution, and residue depletion of oxytetracycline in WS-RLP infected California red abalone Haliotis rufescens

Cited by 14 publications

References 25 publications

Reduced disease in black abalone following mass mortality: phage therapy and natural selection

Reduced disease in black abalone following mass mortality: phage therapy and natural selection

Kinetic analysis of oxytetracycline residues in Chinese mitten crab, Eriocheir sinensis, muscle following intramuscular administration

Histological features of Rickettsia-like organisms in the European flat oyster (Ostrea edulis L.)

Contact Info

Product

Resources

About