Efficacy testing of novel chemical disinfectants on clinically relevant microbial pathogens

Meade, Elaine; Garvey, Mary

doi:10.1016/j.ajic.2017.07.001

Cited by 20 publications

(11 citation statements)

References 17 publications

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“…10 However, chemical disinfection is the most widespread in food processing industry and nosocomial environments due to its effective cost performance, simple application and relatively broad antimicrobial spectrum. [10][11][12][13] Disinfectants are composed of a wide range of active ingredients such as alcohol, chlorine and chlorine compounds, hydrogen peroxide, peracetic acid, phenolics, aldehydes, and quaternary ammonium compounds. 14 Among all, quaternary ammonium compounds (QACs) are vastly utilized in surface disinfection because of its thermal stability, low human toxicity and oxidative properties, low cost and adequate germicidal performance.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Efficiency and Surface Interactions of Quaternary Ammonium Compound Absorbed on Dielectric Barrier Discharge (DBD) Plasma Treated Fiber-Based Wiping Materials

Song

Cvelbar

Stražar

et al. 2019

ACS Appl. Mater. Interfaces

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Efficiency and Surface Interactions of Quaternary Ammonium Compound Absorbed on Dielectric Barrier Discharge (DBD) Plasma Treated Fiber-Based Wiping Materials

Song

Cvelbar

Stražar

et al. 2019

ACS Appl. Mater. Interfaces

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show abstract

“…Resistance problems do not emerge when efficacious surface disinfectants are used properly following instruction for use (IFU) [103]. Two tested antibiotic-resistant microorganisms (MRSA, VRE) resisted to intermediate-level disinfectants in off-label conditions [104]. Recently, seven cleaning-disinfecting wipes and sprays, based on different active ingredients, were tested for their efficacy in removal of microbial burden and proteins in hospital settings.…”

Section: Resistant and Susceptible Strain Survival To Surface Disinfementioning

confidence: 99%

Infection Control in Dentistry and Drug-Resistant Infectious Agents: A Burning Issue. Part 2

Barenghi¹,

Barenghi²,

Blasio³

2020

Surgical Infections - Some Facts

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We showed that antibiotic-resistant bacterial infections inside of dental settings are relevant. Here, we have focused on the limited awareness on infection prevention guidelines, and the lapses and errors during infection prevention, which sustain the evidence of possible reservoirs of antibiotic-resistant bacterial infections in humans (dental staff and patients) and on dental items or in the environment. We chose Staphylococci and Enterobacteriaceae as markers since they are considered as prioritized bacteria according to antibiotic resistance pressure, and the data are available on their virulence factors and for dental settings. For better dental patient and healthcare personnel safety, we need to improve knowledge on bioburden and biofouling, based also on molecular biological methods, and education and training initiatives to limit the hazards in surgical dental settings and to sustain accreditation survey.

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“…DNA amplification, clean-up and gene sequencing of PCR products were completed by Source Bioscience (Waterford, Ireland). Antifungal susceptibility patterns of isolated fungal species to amphotericin, caspofungin and fluconazole was determined using the Kirby Bauer Assay as per the method of Meade, et al [8], and cell inhibitory activity determined by inoculating a single fungal colony in sabouraud broth containing varying antifungal concentrations over night at 30 °C, with viable cell numbers determined via a plate count technique. Antifungal testing of both the cutaneous and urogenital strains of C. kruesi via the Kirby Bauer assay (Figure 1) showed that the urogenital strain was more resistant to both fluconazole and caspofungin at concentrations of 2.5 and 12.5 µg/ml.…”

Section: Case Studymentioning

confidence: 99%

Zoonotic Antimicrobial Resistance as a Result of Iatrogenic Disease in Companion Animals - Case Study Reports

Meade¹,

Anthony²,

Garvey³

2019

J Infect Dis Epidemiol

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Iatrogenic disease represents an ongoing issue for veterinarians where animals manifest with secondary conditions as a result of medical treatment. Similarly, zoonotic disease and specifically resistant zoonotic pathogens represent an ongoing issue for public health safety. As an increasing number of zoonotic microbial species are being recognised as emerging and re-emerging diseases in humans, the issues relating to their antimicrobial resistance becomes more evident. This study reports on two cases of iatrogenic invasive microbial disease in companion animals following previous treatment for dermal conditions. Species identified included Candida krusei, E. coli, MRSA and E. hirae. Furthermore, isolated species both fungal and bacterial were also shown to display antimicrobial resistance. Antifungal resistance in Candida species is an emerging problem particularly as infection with this species has a high mortality rate in immunocompromised persons. Typically, cutaneous infections in companion animals are treated with broad spectrum beta lactamase antibiotics often accompanied with glucocorticoid steroids. This study suggests that more specific diagnostic measures need to be taken to identify the causative agents of infection, to optimise disease treatment and potentially lower the emergence of resistant species.

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Efficacy testing of novel chemical disinfectants on clinically relevant microbial pathogens

Cited by 20 publications

References 17 publications

Antimicrobial Efficiency and Surface Interactions of Quaternary Ammonium Compound Absorbed on Dielectric Barrier Discharge (DBD) Plasma Treated Fiber-Based Wiping Materials

Antimicrobial Efficiency and Surface Interactions of Quaternary Ammonium Compound Absorbed on Dielectric Barrier Discharge (DBD) Plasma Treated Fiber-Based Wiping Materials

Infection Control in Dentistry and Drug-Resistant Infectious Agents: A Burning Issue. Part 2

Zoonotic Antimicrobial Resistance as a Result of Iatrogenic Disease in Companion Animals - Case Study Reports

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