Efficacy Study of Broken Rice Maltodextrin inIn VitroWound Healing Assay

Abstract

Maltodextrins that contain both simple sugars and polymers of saccharides have been widely used as ingredients in food products and pharmaceutical delivery systems. To date, no much work has been reported on the applications of maltodextrin from broken rice (RB) sources. Therefore, the objective of this work was to investigate the in vitro wound healing efficacy of RB maltodextrin at different conditions. Wounds treated with lower dextrose equivalent (DE) range (DE 10–14) of maltodextrins at a concentration of 10% obtained from RB were found to be able to heal the wounds significantly faster (p < 0.01) than maltodextrin with higher DE ranges (DE 15–19 and DE 20–24) and concentrations of 5% and 20%. The findings from both BrdU and MTT assay further confirmed its wound healing properties as the NIH 3T3 fibroblast wounded cells were able to proliferate without causing cytotoxic effect when wounded cell was treated with maltodextrin. All these findings indicated that the RB maltodextrin could perform better than the commercial maltodextrin at the same DE range. This study showed that RB maltodextrins had better functionality properties than other maltodextrin sources and played a beneficial role in wound healing application.

Skin Wound-Healing Potential of Polysaccharides from Medicinal Mushroom Auricularia auricula-judae (Bull.)

“…The results of our study indicate that AAP accelerates the wound-healing process through the promotion of fibroblast and keratinocyte proliferation, migration, and invasion, and the enhancement of collagen synthesis that occurs during the proliferation step of the wound repair process. As was consistent with our study, other medicinal mushroom and plant-based extracts have been verified for wound-healing properties with those targeting various mechanisms, including epithelial and dermal cells stimulation, reduction of reactive oxygen species (ROS), and modulation of inflammatory intermediates [ 25 , 26 ]. The efficiency of the wound-healing process is largely dependent upon the balance of proinflammatory and pro-regenerative signals that are mediated by cytokines [ 27 , 28 ].…”

Non-toxic polyester urethanes based on poly(lactic acid), poly(ethylene glycol) and lysine diisocyanate

“…This revealed the presence of lactic acid, which could explain the diminished viability of the cells. This phenomenon of decreased viability of cells due to the presence of lactic acid was also observed in a study, 42 where identical cell cultures were utilized. Taking into account potential biomedical applications for the PEUs prepared here, further purification treatment would prove capable of reducing cytotoxicity to a greater extent.…”

Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses

“…In the same context, local antibiotics were not used with caution owing to bacterial resistance risk [ 45 ]. Regardless, antibiotics were not used in horses with distal limb wounds, instead of relying on the antibacterial activity of povidone-iodine as an antiseptic and the action of maltodextrin/ascorbic acid gel, which reduces wound pH and causes an osmotic effect that promotes bacterial lysis [ 26 , 50 ]. Furthermore, nonsteroidal anti-inflammatory drugs were specifically avoided since they would have interfered with the treatment’s effectiveness [ 11 , 51 ].…”