Efficacy spectrum of antishivering medications

Park, Sea Mi; Mangat, Halinder S.; Berger, Karen; Rosengart, Axel J.

doi:10.1097/ccm.0b013e31825b931e

Cited by 79 publications

(46 citation statements)

References 130 publications

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“…However, incidences of shivering, due to heat loss from insufflation gas and irrigation fluid and heat redistribution after anesthesia, have been reported to be similar for laparoscopic and open procedures [5][6][7]. Furthermore, although the most commonly used drugs, meperidine and clonidine, have potent anti-shivering effects [8], these may cause hemodynamic and respiratory suppression due to their sympatholytic actions. Five-hydroxytryptamine-3 (5-HT 3 ) receptor antagonists, which have been used to prevent or treat postoperative nausea and vomiting (PONV), have been reported to reduce PAS without inducing hemodynamic or respiratory disturbances [9].…”

Section: Introductionmentioning

confidence: 99%

Implications of palonosetron in elderly patients undergoing laparoscopic cholecystectomy with respect to its anti-shivering effect

Kim

Lee

et al. 2015

Aging Clin Exp Res

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Section: Introductionmentioning

confidence: 99%

Implications of palonosetron in elderly patients undergoing laparoscopic cholecystectomy with respect to its anti-shivering effect

Kim

Lee

et al. 2015

Aging Clin Exp Res

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“…The non-pharmacological management is by external heating like the use of forced air warming, warming blankets, warmed fluids etc., According to the results of a meta-analysis, the most frequently reported pharmacological interventions include clonidine, pethidine, tramadol, nefopam and ketamine. [6] Unfortunately, no gold standard treatment is known for shivering as the administration of all the available drugs is associated with various adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Randomised double-blind comparative study of dexmedetomidine and tramadol for post-spinal anaesthesia shivering

et al. 2014

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Background and Aims:Dexmedetomidine (α2 adrenergic agonist) has been used for prevention of post anaesthesia shivering. Its use for the treatment of post-spinal anaesthesia shivering has not been evaluated. The aim of this study was to evaluate and compare the efficacy, haemodynamic and adverse effects of dexmedetomidine with those of tramadol, when used for control of post-spinal anaesthesia shivering.Methods:A prospective, randomised, and double-blind study was conducted in 50 American Society of Anaesthesiologists Grade I and II patients of either gender, aged between 18 and 65 years, scheduled for various surgical procedures under spinal anaesthesia. The patients were randomised in two groups of 25 patients each to receive either dexmedetomidine 0.5 μg/kg or tramadol 0.5 mg/kg as a slow intravenous bolus. Grade of shivering, onset of shivering, time for cessation of shivering, recurrence, response rate, and adverse effects were observed at scheduled intervals. Unpaired t-test was used for analysing the data.Results:Time taken for cessation of shivering was significantly less with dexmedetomidine when compared to tramadol. Nausea and vomiting was observed only in tramadol group (28% and; 20% respectively). There was not much difference in the sedation profile of both the drugs.Conclusion:We conclude that although both drugs are effective, the time taken for cessation of shivering is less with dexmedetomidine when compared to tramadol. Moreover, dexmedetomidine has negligible adverse effects, whereas tramadol is associated with significant nausea and vomiting.

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“…Shivering can impair pulse oximetry and electrocardiogram monitoring. It can also increase demand for oxygen and production of CO 2 about fourfold,3,4 and may also have a role in the intensification of wound pain, reduced wound healing, and delayed discharge from the recovery unit 5. Therefore, the prevention of shivering is rational and could result in better perioperative outcomes.…”

Section: Introductionmentioning

confidence: 99%

Effects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial

Nasseri¹,

Ghadami²,

Nouri³

2017

DDDT

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BackgroundShivering is among the common troublesome complications of spinal anesthesia (SA), and causes discomfort and discontentment in parturients undergoing cesarean sections (CSs). The aim of this study was to investigate the effects of intrathecal dexmedetomidine in the prevention of shivering in those who underwent CS under SA.Subjects and methodsFifty parturients planned for elective CSs under SA were enrolled in this prospective, double-blinded, controlled study and randomly divided into two equal groups. Spinal block was achieved with 12.5 mg 0.5% heavy bupivacaine plus 5 μg dexmedetomidine (BD group) or 0.5 mL 0.9% normal saline (BN group). The incidence and intensity of shivering, peripheral and core body temperature, hemodynamic parameters, and adverse events was recorded.ResultsThe incidence of shivering was significantly higher in the BN group (52%) than the BD group (24%) (P=0.04). Likewise, the intensity of shivering was significantly higher in the BN group than the BD group (P=0.04). The incidence of adverse events, such as hypotension, nausea/vomiting, and bradycardia, was not significantly different between the two groups, although the grade of sedation was higher in the BD group than the BN group (P=0.004).ConclusionWe conclude that intrathecal dexmedetomidine is effective in lowering the incidence and intensity of shivering in parturients undergoing CSs under SA without major adverse effects.

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Efficacy spectrum of antishivering medications

Cited by 79 publications

References 130 publications

Implications of palonosetron in elderly patients undergoing laparoscopic cholecystectomy with respect to its anti-shivering effect

Implications of palonosetron in elderly patients undergoing laparoscopic cholecystectomy with respect to its anti-shivering effect

Randomised double-blind comparative study of dexmedetomidine and tramadol for post-spinal anaesthesia shivering

Effects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial

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