Efficacy of zinc supplementation in preventing acute hepatitis in Long–Evans Cinnamon rats

Medici, Valentina; Sturniolo, Giacomo Carlo; Santon, Alessandro; D’Incà, R.; Bortolami, Marina; Cardin, Romilda; Basso, Daniela; Albergoni, V.; Irato, Paola

doi:10.1111/j.1478-3231.2005.01108.x

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…In addition, Zn supplementation before the administration of the hepatotoxic agent was able to inhibit liver injury [61][62][63][64][65] and DNA fragmentation during the phase of early liver fibrosis induction [66]. In Long-Evans Cinnamon (LEC) rats, characterized by an abnormal Cu deposition in the liver due to a lack of the Cu transporter P-type adenosine triphosphatase, Zn administration prevented acute hepatitis by increasing tissue MT concentrations, reducing Cu absorption, and interfering with Fe metabolism [67]. It is well documented that liver MT expression increases during acute liver injury [68,69].…”

Section: Alcoholic Hepatitis and Fatty Liver Diseasementioning

confidence: 99%

Zinc and the Liver: An Active Interaction

2007

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Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver function. Decreased zinc levels have been implicated in both acute and chronic liver disease states, and zinc deficiency has been implicated in the pathogenesis of liver diseases. Zinc supplementation offers protection in experimental animal models of acute and chronic liver injury, but these hepatoprotective properties have not been fully elucidated. In the present review, data on zinc homeostasis, its implication in the pathogenesis of liver diseases, and its effect on acute and chronic liver diseases are presented. It is concluded that zinc could protect against liver diseases, although up to now the underlying pathophysiology of zinc and liver interactions have not been defined.

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Section: Alcoholic Hepatitis and Fatty Liver Diseasementioning

confidence: 99%

Zinc and the Liver: An Active Interaction

2007

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“…Iron in excess is toxic, particularly in man, where hemochromatosis (iron overload characterized by hyperabsorption of dietary iron) is one of the most frequent genetic disorders [6], leading in the end-stage to liver cirrhosis. On the other hand, zinc supplementation has shown to prevent acute hepatitis by reducing copper absorption and interfering with iron [7]. Diagnosis of hemochromatosis can be made by biochemical parameters, genetically and/or histologically by liver biopsy [8].…”

Section: Introductionmentioning

confidence: 99%

Iron, copper, zinc and bromine mapping in cirrhotic liver slices from patients with hemochromatosis studied by microscopic synchrotron radiation X-ray fluorescence analysis in continuous scanning mode

Osterode¹,

Falkenberg²,

Höftberger³

et al. 2007

Spectrochimica Acta Part B: Atomic Spectroscopy

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Iron (Fe) and copper (Cu) are essential metals in physiological cell metabolism. While Fe is easy to determine biochemically in histological slices, Cu and zinc (Zn) distribution is frequently critical in confirming the presence of an overload in disturbed Fe/Cu metabolism. To analyze Fe, Cu and Zn in a near histological resolution, energy dispersive microscopic synchrotron radiation X-ray fluorescence was applied.In normal liver tissue, after fixation and imbedding in paraffin, mean Fe, Cu and Zn concentrations were 152 ± 54, 20.1 ± 4.3 and 88.919.5 μg/g sample weight, respectively. No substantial, characteristic differences in their distribution were found in the two-dimensional scans. In slices from patients with hemochromatosis mean Fe, Cu and Zn concentrations were 1102 ± 539, 35.9 ± 14.6 and 27.2 ± 6.7 μg/g sample weight, respectively. Additionally, a significant decrease in phosphorus and sulphur concentrations existed. An increased Cu around cirrhotic regenerations nodules is mostly associated with a lymphocytic infiltration in this region. Analyzing concentrations of Fe in different regions of the samples show a clear negative dependency between Fe and Cu, Cu and Zn, but a positive one between Fe and Zn.Conclusion: With a focal beam size of 15 μm in diameter a resolution of the elemental distribution was achieved which is widely comparable with stained histological slices (20× light microscope). The analysis of simultaneous determined elements reveals metabolic differences between Fe, Cu and Zn in liver tissue from patients with hemochromatosis.

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“…Irato and Albergoni (2005) reported that the administration of Zn after dietary Cu administration are more than doubled intestinal MT concentration, which reduced the Cu concentration to the level of the control values. Medici et al (2005) reported that Zn-induced MT production plays a role in cellular protection against damage caused by excessive Cu accumulation in bee tissues.…”

Section: Discussionmentioning

confidence: 99%

“…A portion of about 1g was taken from each sample and the Pb, Cd, Cu, and Zn concentrations in both the bee bodies and honey samples (honey and beeswax) were determined with an atomic absorption spectrophotometer (Shimadzu, AA 6701F) (Medici et al, 2005). The brains were removed from the frozen bees' heads under and dopamine levels (Harano et al, 2005).…”

Section: Laboratory Analysismentioning

confidence: 99%

Preventive action of zinc against heavy metals toxicity in honeybee

Nisbet¹,

Güler²,

OrmancÄ³

et al. 2018

Afr. J. Biochem. Res.

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A detrimental consequence of industrial growth has been the steady increase in heavy metal pollution which has major, negative impacts on living organisms. Heavy metals still pose a significant health threat, despite the implementation of many strategies to reduce pollution. The aim of this study was to investigate the possible effects of zinc on the accumulation of some heavy metals in honeybees. Groups totalling 15 hives of Apis mellifera were included in this study. Group A was fed sugar syrup, Group B was fed sugar syrup with Cu, Cd and Pb, and Group C was fed sugar syrup with Cu, Cd, Pb and Zn. Food stocks, number of mature worker bees, environment and colony management were standardised across the 15 hives. The data demonstrated that the co-administation of zinc to honeybees, exposed to heavy metals reduced Cu and Cd concentration in tissue samples, but had no effect on Pb concentration. Furthermore, Zn dietary supplementation was effective in reducing both the suppression of dopamine production and the negative effects of heavy metals on dopamine. The results of our study suggest that zinc supplementation in the diet of A. mellifera has a beneficial effect by reducing the cellular accumulation of some heavy metals.

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Efficacy of zinc supplementation in preventing acute hepatitis in Long–Evans Cinnamon rats

Abstract: Zn acetate prevents acute hepatitis, by increasing tissue MT concentrations, reducing Cu absorption and interfering with Fe metabolism.

Cited by 14 publications

References 31 publications

Zinc and the Liver: An Active Interaction

Zinc and the Liver: An Active Interaction

Iron, copper, zinc and bromine mapping in cirrhotic liver slices from patients with hemochromatosis studied by microscopic synchrotron radiation X-ray fluorescence analysis in continuous scanning mode

Preventive action of zinc against heavy metals toxicity in honeybee

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