Efficacy of Zanthoxylum armatum fruit on isoproterenol induced myocardial infarction in rats

Abstract

The present study was elucidating the cardioprotective activity of hydroethanoic extract of Zanthoxylum armatum (Z. armatum) fruit on serum cardiac markers, lipid profile and the level of antioxidants in experimentally induced myocardial infarction (MI). The hydroethanolic extract of Z. armatum fruit was administered at a dose of 200 and 400 mg/kg body weight for 30 days to male Wistar albino rats. On 28th and 29th day, isoproterenol (ISO) (8.5mg/100g body weight) wasadministered to induce MI. Animals were sacrificed; blood and heart tissues were removed and the biochemical parameters were carried out. Serum markers such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB) and troponin –T were significantly (p<0.05) increased after ISO treatment. Altered lipid profile and significant changes in enzymic and non- enzymic antioxidants were also observed in MI. The altered levels were brought back to near normal by the administration of hydroethanoic extract of Z. armatum fruit which might be due to the active phytoconstituents present in it.

Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats

“…These anti-oxidants were markedly increased in ISO treated rats when pre-treated with COMB, which exposing the free radicals scavenging property by having hydroxyl groups. Past outcomes (Mangalanathan et al, 2019, Mounir et al, 2019) are in line with our report.…”