Efficacy of Yishen Huashi Granules Combined with Linagliptin Tablets on Blood Glucose and Renal Function in Patients with Type 2 Diabetic Nephropathy

Abstract

Objective. To probe into the efficacy of Yishen Huashi granules combined with linagliptin tablets in the treatment of type 2 diabetic nephropathy (DN) and its effect on blood glucose and renal function in patients. Methods. 70 patients with type 2 DN at our hospital between May 2020 and May 2022 were chosen as the research objects and separated into the control group and the research group based on their treatments. With 35 cases in each group, the patients treated with initial therapy and linagliptin tablets were enrolled in the control group, and those who received the above treatments and also Yishen Huashi granules were included in the research group. Their clinical indexes such as blood glucose and renal function were compared with both groups after treatment. Results. After treatment, the research group had remarkably lower fasting blood glucose (FPG), 2 h-postprandial blood glucose (2 h-PBG), and glycosylated hemoglobin A1c (HbA1c) levels than those in the control group ( P < 0.05 ). After treatment, the research group had remarkably lower levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) ( P < 0.05 ) and higher high-density lipoprotein (HDL) levels ( P < 0.05 ) than those in the control group. After treatment, the urinary microalbumin (u-mALB) level was remarkably lower in both groups ( P < 0.05 ) and was distinctly lower in the research group than in the control group ( P < 0.05 ). After treatment, the research group had remarkably lower renal function indexes such as serum creatinine (SCr), blood urea nitrogen (BUN), urinary protein (UPro), and urinary albumin excretion rate (UAER) ( P < 0.05 ) and a higher estimated glomerular filtration rate (eGFR) level ( P < 0.05 ) than those in the control group. The efficacy was evaluated by the traditional Chinese medicine (TCM) syndrome score after treatment. There were no patients in complete remission between both the groups, where slight differences were found in the proportion of significant remission ( P > 0.05 ), with the total effective rate of the research group remarkably higher than that of the control group ( P < 0.05 ). Conclusion. The combination of Yishen Huashi granules and linagliptin tablets can reduce the blood glucose and blood lipid levels in patients with type 2 DN and lower UPro and protect renal function at the same time, which provides a new idea and a method for clinical treatment of type 2 DN with integrated traditional Chinese and Western medicine.

Comparative pharmacokinetic studies of Ephedra herba in common cold and nephrotic syndrome rat models

“…Adriamycin‐induced nephrotic syndrome is accompanied by renal dysfunction. Scr and BUN are endogenous substances for evaluating renal function [31]. Compared with the normal group, the serum levels of Scr and BUN were significantly higher ( p < 0.01) in the nephrotic syndrome model group, as shown in Figure 2B,C.…”