Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency

Abstract

Aim: The objective of this study is the evaluation of the effect of vitamin D replacement treatment on musculoskeletal symptoms and quality of life in patients with chronic widespread musculoskeletal pain (CWP) including fibromyalgia (FM) and vitamin D deficiency.Method: Patients with nonspecific CWP and vitamin D deficiency (25-OH D3 < 25 ng/mL) were included into the study. Replacement treatments of 50 000 IU/week oral vitamin D3 for 3 months were given to the patients. Patients were assessed pre-and post-treatment in terms of serum levels of Ca, P, alkaline phosphatase, 25-OH D3, severity of pain (visual analogue scale [VAS]-pain), severity of asthenia (VAS-asthenia), Beck Depression Inventory (BDI), quality of life scale (Short Form [SF]-36), tender point count (TPC), severity of waking unrefreshed, headache, tenderness on tibia, meeting the criteria of FM, and level of patient satisfaction.Results: Fifty-eight patients with a mean age of 36.9 AE 9.2 years were included into the study. 25-OH D3 levels of patients elevated from 10.6 AE 5.1 ng/mL to 46.5 AE 24.0 ng/mL after replacement treatment (P < 0.001). Marked decrease in VAS-pain, VAS-asthenia, severity of waking unrefreshed, TPC, and BDI and an evident increase in subgroups of SF-36 were established in patients after treatment (P < 0.001). The number of FM+ patients was 30 (52%) before treatment and regressed to 20 (34%) after treatment (P = 0.013); 85% of patients stated satisfaction with the treatment.Conclusions: Vitamin D replacement treatment in patients with nonspecific CWP has provided improvements in musculoskeletal symptoms, level of depression and quality of life of patients. Patients with CWP should be investigated for vitamin D deficiency.

Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia

“…However, a higher reduction rates in the FIQ score and BDI score have been suggested as clinically significant by some authors [28]. In a recent study by Yilmaz et al [29] including patients with chronic nonspecific widespread musculoskeletal pain, it was reported that replacement of vitamin D improved the quality of life (SF-36). In another study, there were no correlations found between vitamin D and health status [30].…”

ssessment of the Relationship Between Vitamin D Level and Non-specific Musculoskeletal System Pain: A Multicenter Retrospective Study (Stroke Study Group)

“…Osteomalazi kliniğinde en yaygın yakınma ise sıklıkla pelvis, kosta ve omurgaları içeren yaygın ağrıdır (11). Fiziksel tıp ve rehabilitasyon polikliniklerinde görülen hastaların önemli bir kısmının yakınması da özgül olmayan kas iskelet sistemi ağrılarıdır (24). Günümüzde kronik yaygın ağrı ve DVE arasındaki ilişkiyi araştıran klinik ve toplum çalışmalarının sonuçları çelişkilidir (16,17,24).…”

“…Fiziksel tıp ve rehabilitasyon polikliniklerinde görülen hastaların önemli bir kısmının yakınması da özgül olmayan kas iskelet sistemi ağrılarıdır (24). Günümüzde kronik yaygın ağrı ve DVE arasındaki ilişkiyi araştıran klinik ve toplum çalışmalarının sonuçları çelişkilidir (16,17,24). Yapılan bir toplum çalışmasında, kronik yaygın ağrı ile DVE arasında erkek cinsiyette herhangi bir ilişki saptanmaz iken, kadın cinsiyette ilişkinin istatistiksel olarak anlamlı düzeye ulaştığı bildirilmiştir (25 …”

The interfaces between vitamin D, sleep and pain

“…Researchers have shown that women with 25OHD serum levels <20 ng/mL have a higher chance of developing pain (Table 2) (Hicks et al 2008, Heidari et al 2010. Several studies have indicated that vitamin D supplementation (Table 2) is effective in reducing complaints in specific or nonspecific musculoskeletal pain disorders (Schreuder et al 2012, Gendelman et al 2015, Yilmaz et al 2016, Ghai et al 2017. In a recent meta-analysis (Table 2), Wu and colleagues (Wu et al 2016) 3 months reduced pain in conditions such as myalgia, arthritis and chronic musculoskeletal pain.…”