Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children

Vorilhon, Philippe; Arpajou, Bastien; Roussel, H.; Merlin, Étienne; Pereira, Bruno; Cabaillot, Aurélie

doi:10.1007/s00228-018-2601-7

Cited by 55 publications

(50 citation statements)

References 22 publications

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“…An RCT showed that regular supplement of 1 g of vitamin C decreased the duration of illness but did not decrease the frequency of common cold [ 30 ]. This result was consistent with the finding of a meta-analysis which showed that oral vitamin C supplement between 500 mg and 2 g/day did not decrease the incidence of viral URTI, but shortened the duration of illness by 1.6 days in children younger than 6 years [ 31 ]. In addition, a larger number of RCTs showed that daily supplement of 1 g vitamin C and 30 mg zinc decreased the duration and severity of symptoms in common cold [ 29 ].…”

Section: Antiviral Properties Of Vitamin Csupporting

confidence: 92%

Overview of the possible role of vitamin C in management of COVID-19

2020

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The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients, such as vitamins and minerals, has gained an increasing interest as part of the supportive management of COVID-19. Vitamin C levels in serum and leukocytes are depleted during the acute stage of infection owing to increased metabolic demands. High-dose vitamin C supplement helps to normalise both serum and leukocytes vitamin C levels. Vitamin C has multiple pharmacological characteristics, antiviral, anti-oxidant, anti-inflammatory and immunomodulatory effects, which make it a potential therapeutic option in management of COVID-19. The use of high dose of intravenous vitamin C for management of COVID-19 in China and the United Stated has shown promising results. There were no reported adverse reactions with the short-term use of high dose of vitamin C. Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C in management of COVID-19 show positive results.

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Section: Antiviral Properties Of Vitamin Csupporting

confidence: 92%

Overview of the possible role of vitamin C in management of COVID-19

2020

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“…Specific micronutrients, including vitamins A, D, C, E, B6, and B12, folate, zinc, iron, copper, and selenium, have a synergistic role in the immune response [3]. Malnutrition can compromise the proper functioning of the immune system [2,[13][14][15][16][17]. Several studies highlight the role of micronutrients (trace elements, minerals, and vitamins) in the immunological mechanisms involved in response to infections.…”

Section: Food Allergymentioning

confidence: 99%

Consensus statement of the Italian society of pediatric allergy and immunology for the pragmatic management of children and adolescents with allergic or immunological diseases during the COVID-19 pandemic

Cardinale

Ciprandi

Barberi³

et al. 2020

Ital J Pediatr

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The COVID-19 pandemic has surprised the entire population. The world has had to face an unprecedented pandemic. Only, Spanish flu had similar disastrous consequences. As a result, drastic measures (lockdown) have been adopted worldwide. Healthcare service has been overwhelmed by the extraordinary influx of patients, often requiring high intensity of care. Mortality has been associated with severe comorbidities, including chronic diseases. Patients with frailty were, therefore, the victim of the SARS-COV-2 infection. Allergy and asthma are the most prevalent chronic disorders in children and adolescents, so they need careful attention and, if necessary, an adaptation of their regular treatment plans. Fortunately, at present, young people are less suffering from COVID-19, both as incidence and severity. However, any age, including infancy, could be affected by the pandemic. Based on this background, the Italian Society of Pediatric Allergy and Immunology has felt it necessary to provide a Consensus Statement. This expert panel consensus document offers a rationale to help guide decision-making in the management of children and adolescents with allergic or immunologic diseases.

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“…A vitamin C supplementation would have more impact on the reduction of incidence of colds among great athletes exposed to brief periods of severe physical exercise such as marathon runners (Hemilä and Chalker 2013). A more recent meta-analysis conducted on children underlined that vitamin C intake has no preventive effects but reduces the duration of upper respiratory tract infections (URTI) (Vorilhon et al 2019). Due to the low cost and safety of vitamin C, its supplementation could be justified to reduce the duration and severity of common colds in children and adults, as well as upper respiratory tract infections especially in children under 6 years of age and/or submitted to high frequency of URTI (Hemilä and Chalker 2013;Vorilhon et al 2019).…”

Section: ; Padayatty and Levine 2016)mentioning

confidence: 99%

“…A more recent meta-analysis conducted on children underlined that vitamin C intake has no preventive effects but reduces the duration of upper respiratory tract infections (URTI) (Vorilhon et al 2019). Due to the low cost and safety of vitamin C, its supplementation could be justified to reduce the duration and severity of common colds in children and adults, as well as upper respiratory tract infections especially in children under 6 years of age and/or submitted to high frequency of URTI (Hemilä and Chalker 2013;Vorilhon et al 2019). Moreover, EFSA estimated that the dietary intake of vitamin C contribute to the normal function of the immune system in adults and in children under 3 years of age (EFSA NDA Panel 2009d, 2015b).…”

Section: ; Padayatty and Levine 2016)mentioning

confidence: 99%

Plant Kingdom as Source of Vitamins

Hennebelle¹

2020

Handbook of Dietary Phytochemicals

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A vitamin is an organic substance necessary, in small quantities, for the correct functioning of the metabolism of a living organism. It is an essential nutrient because this substance cannot be synthesized in sufficient quantity by this organism and thus must be provided through the food intake. Each organism has specific needs: a molecule can be a vitamin for one species and not be it for another. It is the case for example of Vitamin C. Some vitamins are water-soluble compounds, including all vitamin Bs (B1, B2, B3, B5, B6, B7, B9, B12) and vitamin C. Others are fat-soluble compounds and encompass vitamins A, D, E, and K. In this chapter, we have chosen to provide an overview of recent literature data only about vitamins provided exclusively or significantly by plant food, in particular vitamins A (as provitaminic carotenoids), B1, B9, C, E, and K1. Vitamins provided by animal food, such as vitamin D or vitamin B12, will be not discussed in this chapter.

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Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children

Cited by 55 publications

References 22 publications

Overview of the possible role of vitamin C in management of COVID-19

Overview of the possible role of vitamin C in management of COVID-19

Consensus statement of the Italian society of pediatric allergy and immunology for the pragmatic management of children and adolescents with allergic or immunological diseases during the COVID-19 pandemic

Plant Kingdom as Source of Vitamins

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