Efficacy of Violet oil, a traditional Iranian formula, in patients with chronic insomnia: A randomized, double-blind, placebo-controlled study

Feyzabadi, Zohre; Rezaeitalab, Fariborz; Badiee, Shapour; Taghipour, Ali; Moharari, Fatemeh; Soltanifar, Atefeh; Ahmadpour, Mohammad Reza

doi:10.1016/j.jep.2017.11.036

Cited by 12 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the lack of relevant information, 14 studies were excluded. The final 4 articles ( 7 , 13 , 14 , 16 ) with 5 clinical trials met our inclusion criteria. Figure 1 shows a detailed selection PRISMA flow chart.…”

Section: Resultsmentioning

confidence: 99%

“…This route of drug delivery has been presented as an important route of drug administration, especially for neurologic disorders ( 25 ). Three of the articles included in this study involved intranasal administration ( 7 , 13 , 16 ). Unfortunately, due to the small number of studies included in this study, we cannot conduct a subgroup analysis on the route of administration to verify.…”

Section: Discussionmentioning

confidence: 99%

“…It is an active ingredient of V. odorata ( 9 ), which can explain its hypnotic and circadian-shifting effects ( 12 ). Over recent years, a growing number of studies have shown that treatment of insomnia with violet oil significantly improved sleep and insomnia severity index scores ( 13 , 14 ). Additionally, it was more effective on sleep quality than sleep quantity ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

“…Over recent years, a growing number of studies have shown that treatment of insomnia with violet oil significantly improved sleep and insomnia severity index scores ( 13 , 14 ). Additionally, it was more effective on sleep quality than sleep quantity ( 13 ). However, the findings on the efficacy of V. odorata in the treatment of insomnia have been controversial.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis

Huang

Zhou

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

AimThis systematic review and meta-analysis was performed to assess the effect of Viola odorata (V. odorata) extract in the treatment of insomnia.MethodsPubMed, EMBASE, and Cochrane Library databases, as well as references of related articles, were searched. Finally, four articles with five clinical trials including 224 patients were included in the analysis.ResultsThe obtained results indicated a greater improvement in total PSQI scores (MD,−4.67; P = 0.0002), subjective sleep quality score (MD,−0.91; P = 0.003), sleep duration score (MD,−0.77; P < 0.00001), and ISI score (MD,−6.30; P = 0.009) in the Viola extract group compared with the placebo group. However, the Viola extract group did not significantly differ in sleep latency (MD,−0.85; P = 0.08), habitual sleep efficiency (MD,−0.61; P = 0.21), sleep disturbances (MD,−0.36; P = 0.11), and daytime dysfunction (MD,−0.94; P = 0.12) from the placebo group.ConclusionsViola extract supplement led to a greater improvement in total PSQI scores, subjective sleep quality score, sleep duration score, and ISI score compared with the placebo group of patients with chronic insomnia.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis

Huang

Zhou

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Wood violet essential oil was studied in patients with chronic insomnia and the outcomes, as measured by ISI, indicated a reduction in symptoms after treatment [141]. In a subsequent trial, volunteers with chronic insomnia demonstrated that this essential oil is more effective than a placebo in severe insomnia [142]. Another clinical trial in which Shirzadegan et al studied the effects of geranium aroma on anxiety in subjects with acute myocardial infarction showed a reduction in anxiety levels; unfortunately, there are no other clinical trials on this species reported in the literature [143].…”

Section: Essential Oilsmentioning

confidence: 99%

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review

2021

View full text Add to dashboard Cite

Sleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. The process entailed a search of PubMed, Scopus, and the Cochrane Library databases from 2010 to 2020. The search terms included “sleep disorder”, “insomnia”, “sedative”, “hypnotic”, “anxiety”, “anxiolytic”, and “clinical trial”, combined with the search terms “herbs” and “medicinal plants”, in addition to individual herbal medicines by both their common and scientific names. This updated review, which focuses mainly on clinical trials, includes research on 23 medicinal plants and their combinations. Essential oils and their associations have also been reviewed. The efficacy of medicinal plants depends on treatment duration, types of study subjects, administration route, and treatment method. More clinical trials with an adequate, standardized design are necessary, as are more preclinical studies to continue studying the mechanisms of action. As a result of our work, we can conclude that the 3 plants with the most potential are valerian, passionflower, and ashwagandha, with the combination of valerian with hops and passionflower giving the best results in the clinical tests.

show abstract

Viola odorata L. (Violaceae)

Akbar

2020

Handbook of 200 Medicinal Plants

View full text Add to dashboard Cite

Efficacy of Violet oil, a traditional Iranian formula, in patients with chronic insomnia: A randomized, double-blind, placebo-controlled study

Cited by 12 publications

References 21 publications

The Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis

The Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review

Viola odorata L. (Violaceae)

Contact Info

Product

Resources

About