Efficacy of various intracanal medicaments against Enterococcus faecalis in primary teeth: An in vivo study

Abstract

The aim of this study was to evaluate the in vivo efficacy of three intracanal medicaments (Ca(OH)2, 1% chlorhexidine gel and 1% chlorhexidine gel with Ca(OH)2 against Enterococcus faecalis in necrotic primary teeth. As a conclusion, chlorhexidine gel with or without Ca(OH)2 was more effective than Ca(OH)2 alone against Enterococcus faecalis.

Antibacterial effectiveness in vitro of different formulations of calcium hydroxide paste

“…This can be achieved through the use of particular vehicles in the formulation of calcium hydroxide pastes, which should be capable of improving diffusion through the canals and increasing the antibacterial effect 11 . In view of this, Ca(OH) 2 powder has been combined with different vehicles, such as distilled water (DW), saline solution, camphorated p-monochlorophenol (CMCP), chlorhexidine, polyethylene glycol, propylene glycol (PG), Otosporin (O), glycerine 12 , and also with chlorhexidine gel [13][14] , in an attempt to improve its antibacterial activity, biocompatibility, speed of ion dissociation and diffusion 11 . Many studies have compared the effectiveness of calcium hydroxide pastes and the use of various vehicles in several respects, namely: the inhibitory behavior towards bacterial infiltration via the crown 15 ; the relationship of each vehicle with the potential for the diffusion of the calcium hydroxide paste into the dentin tubules 16 ; and the degradation of these pastes over the course of time 17 that results in a greater or lesser degree of substantivity and effectiveness against endodontic pathogens.…”

Effect of Two Different Hydrating Solutions on Antibacterial Property of White Mineral Trioxide Aggregate Against Enterococcus Faecalis - An in Vitrocomparative Study

“…Enterococcus faecalis is a facultative anaerobic Gram-positive coccus, that is commonly detected in asymptomatic, persistent endodontic infections and is considered as one of the most resistant microorganisms to calcium hydroxide-based intracanal medications. 1 Inclusion of 2% chlorhexidine (CHX) in combination with sodium hypochlorite are currently the most effective methods to combat E. faecalis. Chlorhexidine is being incorporated in root canal materials for improving prognosis by enhancing the antimicrobial properties of endodontic materials.…”

Efeito antibacteriano e sucesso clínico/radiográfico da pasta de hidróxido de cálcio associada à clorexidina como medicação intracanal no tratamento de dentes decíduos humanos com polpa necrótica

“…Nos últimos anos, tem ocorrido uma mudança nos paradigmas do tratamento endodôntico de dentes decíduos, sendo atualmente mais freqüente a realização do preparo biomecânico 8,31 . Entretanto, foi encontrado apenas um trabalho na literatura que avalia a efetividade desse procedimento na redução da microbiota intracanal em dentes decíduos 13 [16][17]34,58 .…”

“…Pesquisas in vitro 9,11,17 e in vivo realizadas em animais 38 e em dentes permanentes humanos 10,69,26 avaliando a atividade antibacteriana da pasta de hidróxido de cálcio associada à clorexidina têm mostrado resultados contraditórios, e, o uso desta associação em dentes decíduos tem sido pouco pesquisado 31 . Em função da escassez de trabalhos em dentes decíduos, é de grande importância a realização de pesquisas que identifiquem e quantifiquem, por meio de técnicas mais sensíveis de biologia molecular, os microrganismos envolvidos na infecção endodôntica desses dentes na presença de necrose pulpar com e sem lesão radiográfica na região de furca/periapical, assim como, que avaliem o efeito do preparo biomecânico e da associação do hidróxido de cálcio com a clorexidina como medicação intracanal sobre a microbiota identificada.…”