Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age

The medical management of abnormal uterine bleeding in reproductive-aged women

“…72 Larger studies are needed to determine the utility of lower-dose danazol in the treatment of AUB. Leuprolide acetate is FDA-approved for short-term use in the preoperative treatment of uterine leiomyomata to delay surgery and, potentially, reduce intraoperative blood loss.…”

Comparison of the Intraoperative Outcomes of Intrauterine Instillation of Epsilon-Aminocaproic Acid and Intravenous Oxytocin in Hysteroscopy Surgeries

“…This study showed that, in contrast to ours, oxytocin was superior in stabilizing hemodynamic state and hematologic profile. It was also more effective in reducing blood transfusion (12). It should be noted that although tranexamic acid and EACA are similar drugs, their action might differ in preventing uterine bleeding.…”

“…Intravenous oxytocin, on the other hand, is an uterotonic medication that reduces bleeding through stimulating the uterine smooth muscle contraction and subsequent vascular luminal narrowing (11). Although generally considered as a rather safe medication, oxytocin may cause serious complications such as urinary retention and hypotension (12). This study seeks to compare efficacies and side effects of using EACA at a higher than conventional dose and intravenous oxytocin in females with intractable moderate uterine bleeding.…”

Vaginal danazol for women with rectovaginal endometriosis and pain symptoms persisting after insertion of a levonorgestrel‐releasing intrauterine device

“…However, it seems unlikely that treatment with danazol for 6 months would have long-term detrimental effects on these parameters. It has previously been shown that vaginal danazol does not result in significant changes in metabolic or thrombophilic parameters [13,15]. In addition, a recent study showed that treatment with an LNG-IUD for 6 months leads to a significant reduction in serum lipids and other cardiovascular risk markers (such as C-reactive protein) [6].…”

“…In contrast, vaginally administered danazol improves pain symptoms caused by endometriosis with minimal adverse effects [12,13]. The daily administration of vaginal danazol does not affect the pituitary-ovarian axis [14] and does not inhibit ovulation [15].…”