Efficacy of ultrasound-guided cryoablation in treating low-risk breast cancer

Navarro, M.J. Roca; Alonso, Diego Garrido; Monforte, Y. Navarro; Martínez, F. García; Durbán, T. Díaz de Bustamante; Chicote, M.V. Córdoba; Goldaracena, J.M. Oliver

doi:10.1016/j.rxeng.2023.03.002

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…The bag was placed on the breast skin, shielded with surgical gauze and copious ultrasound gel to avoid adhesions. Saline hydrodissection, as described by other authors, was not practiced [ 11 , 12 ].…”

Section: Methodsmentioning

confidence: 99%

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Pre-surgical cryoablation in ≤ 2 cm ER + /HER2-tumors. Prognostic factors for the presence of residual invasive carcinoma

Roca Navarro,

Oliver Goldaracena,

Garrido Alonso

et al. 2024

Breast Cancer Res Treat

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Background Breast cancer remains the most commonly diagnosed cancer in women. Breast-conserving surgery (BCS) is the standard approach for small low-risk tumors. If the efficacy of cryoablation is demonstrated, it could provide a minimally invasive alternative to surgery. Purpose To determine the success of ultrasound-guided cryoablation in achieving the absence of Residual Invasive Cancer (RIC) for patients with ER + /HER2- tumors ≤ 2cm and sonographically negative axillary nodes. Materials and Methods This prospective study was carried out from April 2021 to June 2023, and involved 60 preoperative cryoablation procedures on ultrasound-visible, node-negative (cN0) infiltrating ductal carcinomas (IDC). Standard diagnostic imaging included mammography and tomosynthesis, supplemented by ultrasound-guided biopsy. MRI was performed in patients with associated intraductal carcinoma (DCIS) and an invasive component on core needle biopsy (18 out of 22 cases). All tumors were tagged with ferromagnetic seeds. A triple-phase protocol (freezing–thawing-freezing) with Argon was used, with an average procedure duration of 40 min. A logistic regression model was applied to determine significant correlation between RIC and the study variables. Results Fifty-nine women (mean age 63 ± 8 years) with sixty low-risk unifocal IDC underwent cryoablation prior to surgery. Pathological examination of lumpectomy specimens post-cryoablation revealed RIC in only one of 38 patients with pure IDC and in 4 of 22 mixed IDC/DCIS cases. All treated tumors had clear surgical margins, with no significant procedural complications. Conclusions Cryoablation was effective in eradicating 97% of pure infiltrating ER + /HER2-tumors ≤ 2cm, demonstrating its potential as a surgical alternative in selected patients. Graphical Abstract

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Section: Methodsmentioning

confidence: 99%

“…In the light of these findings and the advantages of this technique, we aim to assess its efficacy in patients with indication for BCS [ 9 , 10 ]. Initial results from the first 20 cases in this study were published in 2022 [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Pre-surgical cryoablation in ≤ 2 cm ER + /HER2-tumors. Prognostic factors for the presence of residual invasive carcinoma

Roca Navarro,

Oliver Goldaracena,

Garrido Alonso

et al. 2024

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…In the light of these ndings and the advantages of this technique, we aim to assess its e cacy in patients with indication for BCS [9], [10]. Initial results from the rst 20 cases in this study were published in 2022 [11], [12] In the present study, we performed pre-surgical cryoablation in 60 in ltrating ductal carcinomas (IDC) measuring up to 2cm and analyzed the surgical specimens to demonstrate that, for a selected group of patients, cryoablation can be used as an alternative to surgery.…”

Section: Introductionmentioning

confidence: 99%

Pre-surgical Cryoablation in≤ 2cm ER+HER2-tumors. Prognostic factors for the presence of residual invasive carcinoma

Navarro,

Goldaracena,

Alonso

et al. 2024

Preprint

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Background: Breast cancer remains the most commonly diagnosed cancer in women. Breast-conserving surgery (BCS) is the standard approach for small low-risk tumors. If the efficacy of cryoablation is demonstrated, it could provide a minimally invasive alternative to surgery. Purpose: To determine the success of ultrasound-guided cryoablation in achieving the absence of Residual Invasive Cancer (RIC) for patients with ER+/HER2- tumors ≤ 2cm and sonographically negative axillary nodes. Materials and Methods: This prospective study was carried out from April 2021 to June 2023, and involved 60 preoperative cryoablation procedures on ultrasound-visible, node-negative (cN0) infiltrating ductal carcinomas (IDC). Standard diagnostic imaging included mammography and tomosynthesis, supplemented by ultrasound-guided biopsy. MRI was performed in patients with associated intraductal carcinoma (DCIS) and an invasive component on core needle biopsy (18 out of 22 cases). All tumors were tagged with ferromagnetic seeds. A triple-phase protocol (freezing-thawing-freezing) with Argon was used, with an average procedure duration of 40 minutes. A logistic regression model was applied to determine significant correlation between RIC and the study variables. Results: Fifty-nine women (mean age 63 ± 8 years) with sixty low-risk unifocal IDC underwent cryoablation prior to surgery. Pathological examination of lumpectomy specimens post-cryoablation revealed RIC in only one of 38 patients with pure IDC and in 4 of 22 mixed IDC/DCIS cases. All treated tumors had clear surgical margins, with no significant procedural complications. Conclusions: Cryoablation was effective in eradicating 97% of pure infiltrating ER+/HER2-tumors ≤ 2cm, demonstrating its potential as a surgical alternative in selected patients.

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Efficacy of ultrasound-guided cryoablation in treating low-risk breast cancer

Cited by 2 publications

References 13 publications

Pre-surgical cryoablation in ≤ 2 cm ER + /HER2-tumors. Prognostic factors for the presence of residual invasive carcinoma

Pre-surgical cryoablation in ≤ 2 cm ER + /HER2-tumors. Prognostic factors for the presence of residual invasive carcinoma

Pre-surgical Cryoablation in≤ 2cm ER+HER2-tumors. Prognostic factors for the presence of residual invasive carcinoma

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