Efficacy of two intervals and two routes of administration of misoprostol for termination of early pregnancy: a randomised controlled equivalence trial

Hertzen, Helena von; Piaggio, Gilda; Huong, Nguyen Thi My; Arustamyan, Karine; Cabezas, Evelio; Gómez, M. Dómine; Khomassuridze, Archil; Shah, Rashmi; Mittal, Suneeta; Nair, Rajasekharan; Erdenetungalag, Radnaabazar; Huong, To Minh; Vy, Nguyen Duc; Phuong, Nguyen Thị; Tuyet, Hoang Thi Diem; Peregoudov, Alexandre

doi:10.1016/s0140-6736(07)60914-3

Cited by 96 publications

(82 citation statements)

References 16 publications

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“…1 Misoprostol forms part of the medication abortion regimen recommended by the World Health Organization (WHO), which consists of the administration of mifepristone followed by misoprostol. 2 In countries in which mifepristone is not available, misoprostol can be used alone to induce abortions, with an effectiveness of 84-96%. 3 When misoprostol is used alone, WHO recommends a dosage of 800 mcg administered vaginally every 24 hours for up to three doses, until 63 days of gestation.…”

Section: How Often and Under Which Circumstances Do Mexican Pharmacy mentioning

confidence: 99%

“…3 When misoprostol is used alone, WHO recommends a dosage of 800 mcg administered vaginally every 24 hours for up to three doses, until 63 days of gestation. 2 Since 1985, misoprostol has been sold in Mexican pharmacies under the commercial name Cytotec, but the prices and prescription requirement to purchase it vary. 4 Cytotec belongs to drug group IV (including antibiotics, steroids, antihypertensive and antiseizure drugs); regulations require that medications in this group be sold by prescription only.…”

Section: How Often and Under Which Circumstances Do Mexican Pharmacy mentioning

confidence: 99%

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How Often and Under Which Circumstances Do Mexican Pharmacy Vendors Recommend Misoprostol To Induce an Abortion?

Lara¹,

García²,

Wilson³

et al. 2011

IPSRH

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Section: How Often and Under Which Circumstances Do Mexican Pharmacy mentioning

confidence: 99%

Section: How Often and Under Which Circumstances Do Mexican Pharmacy mentioning

confidence: 99%

How Often and Under Which Circumstances Do Mexican Pharmacy Vendors Recommend Misoprostol To Induce an Abortion?

Lara¹,

García²,

Wilson³

et al. 2011

IPSRH

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“…16,17 We also noted that women having vaginal bleeding earlier (<2 hrs) following misoprostol administration had significantly more successful termination as compared to women with bleeding after two hours. Further studies are needed to explain and justify this finding.…”

Section: Discussionmentioning

confidence: 65%

A Randomized Trial of Hospital Vs Home Self Administration of Vaginal Misoprostol for Medical Abortion

Shrestha¹,

Sedhai²

2015

Kathmandu Univ. Med. J.

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BackgroundA combination of mifepristone followed after 24 hrs by misoprostol has proved a safe and effective abortifacient for termination of early pregnancy. Home use of misoprostol for medical abortion is still controversial in many countries including ours where women's literacy rate is low. Particularly in developing countries, this method markedly decreased the hospital visit which would be beneficial to patients and hospital staff. ObjectiveTo see whether the home self administration of vaginal misoprostol was equally effective as administered by trained staff in terms of successful termination of early pregnancy. Secondary outcomes were bleeding and pain duration during medical abortion, side effects, reason for termination of pregnancy and women's acceptability of the procedure. MethodOne hundred and eighty eight women requesting medical abortion with pregnancy less than 63 days gestation were randomized into two groups either self administration of vaginal misoprostol (800 mcg) at home or hospital administration 24 hours after oral 200 mg mifepristone. Ultrasound was performed after 14 days to confirm complete abortion. ResultThe overall success rate was similar in two groups: 89.13% on home group Vs 86.9% in hospital group. Eleven out of 18 women (61.1%) having incomplete abortion had successful termination after 2 nd dose misoprostol( 400 mcg). None of the women had continued pregnancy. Multigravida had slightly higher risk of failure (R.R: 1.04). ConclusionHome self administration of vaginal misoprostol was safe and effective for early termination of medical abortion and was acceptable. Use of extra dose of misoprostol has advantage of higher completion rate of abortion.

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“…13,14 Although use of misoprostol alone is less effective than its use with mifepristone, misoprostol-only abortions are nevertheless a safe, acceptable and effective means of early pregnancy termination. 6,15,16 In still other settings, women lack access to both misoprostol and mifepristone. These include much of northern and western Africa; some parts of middle, eastern and southern Africa; and a number of countries in Asia and South America.…”

Section: 10mentioning

confidence: 99%

Use of Medicines Changing the Face of Abortion

Winikoff¹,

Sheldon²

2012

IPSRH

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Efficacy of two intervals and two routes of administration of misoprostol for termination of early pregnancy: a randomised controlled equivalence trial

Cited by 96 publications

References 16 publications

How Often and Under Which Circumstances Do Mexican Pharmacy Vendors Recommend Misoprostol To Induce an Abortion?

How Often and Under Which Circumstances Do Mexican Pharmacy Vendors Recommend Misoprostol To Induce an Abortion?

A Randomized Trial of Hospital Vs Home Self Administration of Vaginal Misoprostol for Medical Abortion

Use of Medicines Changing the Face of Abortion

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