Efficacy of two formulations of afoxolaner (NexGard® and NexGard Spectra®) for the treatment of generalised demodicosis in dogs, in veterinary dermatology referral centers in Europe

Lebon, Wilfried; Beccati, Massimo; Bourdeau, P.; Brément, Thomas; Bruet, Vincent; Cekiera, Agnieszka; Crosaz, Odile; Darmon, Céline; Guillot, Jacques; Mosca, Marion; Pin, Didier; Popiel, Jarosław; Handwerker, Dorota Pomorska; Larsen, Diane; Tielemans, Eric; Beugnet, Frédéric; Halos, Lénaïg

doi:10.1186/s13071-018-3083-2

Cited by 25 publications

(30 citation statements)

References 23 publications

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“…The only dog needing administration every two weeks was on immunosuppressive therapy for pemphigus foliaceus that became mite‐positive when the interval was increased to four weeks, but remained mite‐negative when afoxolaner was administered every two weeks . In a further study, 50 dogs with generalized demodicosis were treated with afoxolaner alone (Nexgard ® ) or combined with milbemycin (Nexgard Spectra ® ) with 2.5–2.7 mg/kg once monthly and the number of mites on skin scrapings was reduced by 87.6%, 96.5% and 98.1% on days 28, 56 and 84, respectively, and 36 of 50 dogs had negative skin scrapings after three months A more recent study looked at afoxolaner combined with milbemycin (Nexgard Spectra ® ) at the dosage of 2.5–6.3 mg/kg p.o. every four weeks in dogs with juvenile‐onset (n = 4) and adult‐onset (n = 11) generalized demodicosis with a variety of clinical lesions.…”

Section: Treatmentmentioning

confidence: 99%

Diagnosis and treatment of demodicosis in dogs and cats

Mueller¹,

Rosenkrantz²,

Bensignor³

et al. 2020

Veterinary Dermatology

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Background Demodicosis is a common disease in small animal veterinary practice worldwide with a variety of diagnostic and therapeutic options. Objectives To provide consensus recommendations on the diagnosis, prevention and treatment of demodicosis in dogs and cats. Methods and materials The authors served as a Guideline Panel (GP) and reviewed the literature available before December 2018. The GP prepared a detailed literature review and made recommendations on selected topics. A draft of the document was presented at the North American Veterinary Dermatology Forum in Maui, HI, USA (May 2018) and at the European Veterinary Dermatology Congress in Dubrovnik, Croatia (September 2018) and was made available via the World Wide Web to the member organizations of the World Association for Veterinary Dermatology for a period of three months. Comments were solicited and responses were incorporated into the final document. Conclusions In young dogs with generalized demodicosis, genetic and immunological factors seem to play a role in the pathogenesis and affected dogs should not be bred. In old dogs and cats, underlying immunosuppressive conditions contributing to demodicosis should be explored. Deep skin scrapings are the diagnostic gold standard for demodicosis, but trichograms and tape squeeze preparations may also be useful under certain circumstances. Amitraz, macrocyclic lactones and more recently isoxazolines have all demonstrated good efficacy in the treatment of canine demodicosis. Therapeutic selection should be guided by local drug legislation, drug availability and individual case parameters. Evidence for successful treatment of feline demodicosis is strongest for lime sulfur dips and amitraz baths.

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Section: Treatmentmentioning

confidence: 99%

Diagnosis and treatment of demodicosis in dogs and cats

Mueller¹,

Rosenkrantz²,

Bensignor³

et al. 2020

Veterinary Dermatology

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“…Where necessary (e.g. long or medium-haired dogs), hair was removed at the area to be scraped, and the skin was rmly squeezed prior to and during scraping to eject mites from hair follicles [2,14,15]. Scrapings were made in the direction of hair growth with a blade or spatula, covered with mineral oil, until capillary oozing was observed.…”

Section: Assessments Of Demodicosismentioning

confidence: 99%

A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of dogs with generalized demodicosis

Petersen

Chiummo

Zschiesche

et al. 2020

Preprint

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Background : Recent reports indicate that the isoxazoline compounds have the potential to provide safe and effective treatment of canine generalized demodicosis, a condition that has been traditionally difficult to cure. Controlled field studies are needed to confirm this potential. A study was therefore initiated to investigate the efficacy of a single oral or spot-on treatment with fluralaner, an isoxazoline, compared with multiple topical treatments with imidacloprid-moxidectin, in dogs naturally affected by generalized demodicosis. Methods : Veterinary clinics in 5 European countries enrolled 134 dogs diagnosed with generalized demodicosis. Dogs were randomized to treatment with either fluralaner chewables, fluralaner spot-on, or topical imidacloprid-moxidectin in a 2:2:1 ratio. Both fluralaner formulations were administered once, at the approved dose rate, on day 0. Imidacloprid-moxidectin was administered per label on day 0, and every 4 weeks, more frequently if necessary. At each visit (days 0, 28, 56, 84), dogs were monitored for demodectic mites, using deep skin scrapings, and observed for health and for severity of skin lesions. Treatment was considered efficacious if more than 90% of the dogs were free of live mites at both days 56 and 84. Results : Of 124 dogs completing the study, 57 were diagnosed with juvenile-onset demodicosis and 67 with the adult-onset form. A single treatment with oral or spot-on fluralaner was efficacious, each eliminating mites from at least 98.0% of treated dogs on days 56 and 84. Against juvenile-onset demodicosis, efficacy of the oral and spot-on formulations was 96.0% and 100%, respectively, and against adult-onset demodicosis 100% and 96.7%. Multiple administrations of imidacloprid-moxidectin were not efficacious, eliminating mites from 87.5% of dogs (92.0% with juvenile-onset demodicosis cured; 81.8% with adult-onset demodicosis). All groups showed a marked reduction in skin lesions by day 28, with continuing clinical improvement at each subsequent visit through day 84. There were no treatment-related adverse events. Conclusion : A single administration of fluralaner chewables or fluralaner spot-on is highly effective against juvenile-onset and adult-onset forms of generalized canine demodicosis. Topically applied imidacloprid-moxidectin at weekly to monthly intervals over the 84-day study did not achieve the proportion of mite-free dogs required to demonstrate efficacy.

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“…The efficacy of the treatment of demodicosis with isoxazolines has been described (Six et al, 2016;Snyder et al, 2017;Lebon et al, 2018). The oral treatment of this disease with fluralaner was effective as observed by other authors (Fourie et al, 2015;Bezerra et al, 2017;Duangkaew et al, 2018) with a single-dose administration.…”

Section: Discussionmentioning

confidence: 65%