Efficacy of two formulations (‘injectable’ and ‘pour on’) of moxidectin against gastrointestinal nematode infections in grazing cattle

Whang, E.; Bauer, C.; Kollmann, D.; Bürger, Harald

doi:10.1016/0304-4017(94)90165-1

Cited by 26 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pour-ons and injectable parasiticides are longer acting as compared to oral dewormers for ecto and endo parasites (Thomas 2008), and pour-on formulation gives a sharper rise in plasma concentration than injectable formulation of avermectins (Herd et al 1996). Anthelmintic efficacy of pour-on macrocyclic lactone has been reported to be better than an injectable formulation (Whang et al 1994). However, pour-on formulations of macrocyclic lactons have lower efficacy than those of pyrethroids (George et al 2008).…”

Section: Discussionmentioning

confidence: 96%

Prevalence, associated determinants, and in vivo chemotherapeutic control of hard ticks (Acari: Ixodidae) infesting domestic goats (Capra hircus) of lower Punjab, Pakistan

Sajid¹,

Iqbal²,

Khan³

et al. 2010

Parasitol Res

View full text Add to dashboard Cite

A total of 800 goats of various breeds, age, and sex were randomly selected from Muzaffargarh (M. garh) and Layyah districts of lower Punjab, Pakistan. The selected goats were visited twice a month to collect information about determinants influencing goat tick infestation prevalence. For acaricidal efficacy, 360 tick-infested adult goats were subjected to an acaricidal treatment and post-treatment quantitative assessment of tick burden. Quantification of adult tick detachment 24 h post-treatment and the duration of treatment efficacy were calculated. Overall prevalence of goat tick infestation in both study districts was 60.1% (481/800). The prevalence was higher in district M. garh than in district Layyah. Tehsil-wise prevalence in district Layyah was highest in tehsil Layyah followed in order by Chaubara and Karor. In district M. garh, highest prevalence was found in tehsil M. garh followed by Kot Addu, Alipur, and Jatoi. Hyalomma a. anatolicum (75.9%; 365/481) and Rhipicephalus sanguineus (24.1%; 116/481) were the predominant species in both the districts. The highest month-wise prevalence was 56.9% and 62.7% in Layyah and M. garh districts, respectively, during July 2008, and the minimum (0%) prevalence was reported in November and December, respectively. Regarding host determinants, female goats were more heavily infested (72.8%) than males (47.5%), and younger animals were (63.5%) more burdened than older ones (56.7%). Teddy goats were the most susceptible breeds followed in order by Beetal, cross-bred, Nachi, and Dera Din Pannah. The preferred sites of attachment were inside and outside of the ear. Both the ivermectin (IVM)- and cypermethrin (CYM)-treated groups resulted in significantly lower (P < 0.05) tick counts relative to controls on all post-treatment counting days. The lowest tick burden in the IVM-treated group was significantly higher (P < 0.05) as compared to the CYM-treated group, the latter being close to zero. Hence, the in vivo efficacy trials of injectable IVM vs CYM pour-on revealed better results for the latter. These observations provided the first insights into what determinants impact goat tick infestation, and laid a foundation for planning of future control programs in the lower Punjab, Pakistan.

show abstract

Section: Discussionmentioning

confidence: 96%

Prevalence, associated determinants, and in vivo chemotherapeutic control of hard ticks (Acari: Ixodidae) infesting domestic goats (Capra hircus) of lower Punjab, Pakistan

Sajid¹,

Iqbal²,

Khan³

et al. 2010

Parasitol Res

View full text Add to dashboard Cite

show abstract

“…Gayrard et al (1999) proved that Ivermectin and Doramectin could be successfully used for control of gastrointestinal parasites in cattle (Gayrard et al, 1999). Whang et al (1994) reported which pour on and injection administration of Moxidectin has positive effect more than 90% on gastrointestinal nematodes and significant different between these two types of administration were not reported (Whang et al, 1994). In two studies by Williams et al (1996) indicated that Moxidectin has very important role for control of parasitic diseases (Williams et al, 1996;Williams and DeRosa, 2003).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Ivermectin Pour-on Administration Against Natural Heterakis gallinarum Infestation and its Prevalence in Native Poultry

Khayatnouri¹

2011

American Journal of Animal and Veterinary Sciences

View full text Add to dashboard Cite

Problem statement: One of the real problems that cause the economic prejudice in animal farms yearly is parasitic diseases. To overcome these problems the use of antiparasitic drugs is necessary. Ivermectin is a broad spectrum antiparasitic agent and different routes of its administration such as injection, oral and pour-on were used. The aims of the current study were evaluation of the efficacy of ivermectin pour-on administration against natural Heterakis gallinarum infection in native poultry and also determination the prevalence rate of this parasite in Tabriz area. Approach:In the present study, 120 native poultry were investigated by Egg Per Gram of feces (EPG) feces test. Willis method was applied for feces test and Mack-master slide method was used for counting nematode eggs. After confirming the infection with worms, Ivermectin (0.5 mg kg⁻¹) pour-on was administrated to infected birds. Fecal examination was repeated in 1, 7, 21 and 28 days post treatment. Results: Results showed that total prevalence of Heterakis gallinarum infection was 21.66% in native poultry of Tabriz area. Efficacy rate of ivermectin pour-on was 59.14, 87.87, 97.65 and 99.57% in 1, 7, 21 and 28 days respectively. Conclusion: In conclusion, the effect of this drug against Heterakis gallinarum resulted in reduction in egg count exceeded 98% (p<0.05), so this drug can be used in antiparasitic program in poultry. Further investigations are necessary to evaluate the drug effect on other nematodes and parasitic infections

show abstract

“…Each member of the macrocyclic lactones may exert a similar mode of antiparasitic action but there is a variation in the efficacy, which is presumed to relate to variations in the chemical structure [3]. Moxidectin is effective at a relatively low dosage (0.2 mg/kg) against a wide variety of nematodes and arthropod parasites in cow [4] and sheep [5].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs

Vanapalli

Hung

Fleckenstein

et al. 2002

Biopharm & Drug Disp

View full text Add to dashboard Cite

show abstract

Efficacy of two formulations (‘injectable’ and ‘pour on’) of moxidectin against gastrointestinal nematode infections in grazing cattle

Cited by 26 publications

References 5 publications

Prevalence, associated determinants, and in vivo chemotherapeutic control of hard ticks (Acari: Ixodidae) infesting domestic goats (Capra hircus) of lower Punjab, Pakistan

Prevalence, associated determinants, and in vivo chemotherapeutic control of hard ticks (Acari: Ixodidae) infesting domestic goats (Capra hircus) of lower Punjab, Pakistan

The Effect of Ivermectin Pour-on Administration Against Natural Heterakis gallinarum Infestation and its Prevalence in Native Poultry

Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs

Contact Info

Product

Resources

About