Efficacy of Trimethoprim-Sulfamethoxazole Against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus: A Report from Tunisia

Jemni, L.; Hmouda, Houssem; Létaief, A.

doi:10.1093/clinids/19.1.202

Cited by 26 publications

(14 citation statements)

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“…This patient's initial isolate from the blood was susceptible to cotrimoxazole but after 10 days of treatment, an isolate recovered from the bone was resistant. 67 The development of resistance while on treatment was not reported in the treatment failures in the previous study. 66 An experimental MSSA and MRSA endocarditis model has demonstrated the superiority of cloxacillin and glycopeptides over cotrimoxazole and this study did not support the use of cotrimoxazole in the treatment of severe staphylococcal infections, including endocarditis and infections with high bacterial loads.…”

Section: Emergence Of Infections Caused By Community-acquired Methicimentioning

confidence: 81%

Diagnosis and management of Staphylococcus aureus infections of the skin and soft tissue

Roberts¹,

Chambers²

2005

Internal Medicine Journal

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Infections involving the skin and soft tissue are common and range from superficial, localized and sometimes self-limiting infections to deep, rapidly spreading and potentially life-threatening infections. Skin infections caused by Staphylococcus aureus include primary pyodermas, while those involving the soft tissues include cellulitis and pyomyositis. Surgical site infections and infections in intravenous drug users are also commonly caused by S. aureus. The severity of the infection determines the choice of treatment. There are few studies that have critically appraised the use of antibiotics in skin and soft tissue infections, and most guidelines are based on expert opinion. The beta-lactam group of antibiotics are the mainstay of treatment for methicillin-susceptible S. aureus infections. For methicillin-resistant S. aureus (MRSA) infections, both with community-acquired and hospital-acquired strains--which are becoming an increasing problem--the antibiotic choice is determined by local susceptibility patterns. Macrolides, clindamycin and cotrimoxazole are options for community-acquired MRSA, while vancomycin is reserved for treatment of infections caused by multiresistant MRSA strains and for patients with suspected endocarditis or severe sepsis. Although a number of the newer antibiotics such as linezolid and quinopristin/dalfopristin have been shown to have good activity against MRSA, these agents should only be used with specialist advice.

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Section: Emergence Of Infections Caused By Community-acquired Methicimentioning

confidence: 81%

Diagnosis and management of Staphylococcus aureus infections of the skin and soft tissue

Roberts¹,

Chambers²

2005

Internal Medicine Journal

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“…Rifampin, in addition to clindamycin or trimethoprim/ sulfamethoxazole, is used by some investigators to diminish the potential for further development of antibiotic resistance. 10,[51][52][53]55 Vancomycin is recommended for patients who are critically ill with suggested skin or soft tissue CAMRSA infection. 8,9,16,19,34,36,51 MRSA should be confirmed by culture because vancomycin is less rapidly bacteriocidal and less efficacious than the beta-lactams (such as cefazolin) and the semisynthetic penicillinase-resistant penicillins (such as oxacillin and nafcillin) against MSSA.…”

mentioning

confidence: 99%

Management of cutaneous lesions associated with an emerging epidemic: community-acquired methicillin-resistant Staphylococcus aureus skin infections

Cohen

Grossman

2004

Journal of the American Academy of Dermatology

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“…In the study of Jemni et al ., all eight patients treated by the combination of cotrimoxazole and rifampin for treatment of infections due to MRSA were cured. [18] Considering increased rate of resistance among S. aureus strains, it is urgent for the worldwide medical community to reexamine the clinical efficacy of older active therapies, such as cotrimoxazole, for treating severe infections due to these pathogens.…”

Section: Discussionmentioning

confidence: 99%

Double-disk synergy test for detection of synergistic effect between antibiotics against nosocomial strains of staphylococcus aureus

2012

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Objective:Synergistic effect between commonly used antibiotics against nosocomial multidrug-resistant strains of Staphylococcus aureus, if present, could provide a viable option as an alternative therapy for infections due to this pathogen. The aim of this study was searching for any synergistic effect between several antibiotics against drug-resistant strains of S. aureus with nosocomial origin using double-disk synergy test and to determine the applicability of this test for such a purpose.Methods:Over a 6-month period, strains of S. aureus isolated from clinical specimens of hospitalized patients with documented nosocomial infection underwent disk diffusion test using antibiotic disks of oxacillin, cephalothin, clindamycin, ciprofloxacin, vancomycin, cotrimoxazole, rifampin, erythromycin, gentamicin and meropenem. Double-disk synergy test was performed for all isolates resistant to at least two of applied antibiotics. Combinations of all possible pairs of antibiotics (to which the microorganism was resistant) were tested by placing antibiotic disks at distance of 20 mm from each other (center to center). After 16- 20 hours of incubation, if synergistic effect was present among two antibiotics, an inhibition zone was formed between their disks.Findings:Among all of possible two-antibiotic combinations tested for 41 resistant isolates, only two cases of synergistic effect were detected; both effects were among rifampin and cotrimoxazole.Conclusion:The combination of rifampin and cotrimoxazole could provide a viable option for treatment of infections due to resistant strains of S. aureus; however, clinical trials are needed before any new recommendation. Also, double-disk synergy test seems to be capable of detecting the synergistic effect between antibiotics at in vitro level.

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Efficacy of Trimethoprim-Sulfamethoxazole Against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus: A Report from Tunisia

Cited by 26 publications

References 0 publications

Diagnosis and management of Staphylococcus aureus infections of the skin and soft tissue

Diagnosis and management of Staphylococcus aureus infections of the skin and soft tissue

Management of cutaneous lesions associated with an emerging epidemic: community-acquired methicillin-resistant Staphylococcus aureus skin infections

Double-disk synergy test for detection of synergistic effect between antibiotics against nosocomial strains of staphylococcus aureus

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