Efficacy of transcranial direct current stimulation (tDCS) as a treatment for persistent hallucinations in patients with schizophrenia: A systematic review and meta-analysis

H, Lee; Chan, Pui Ying; Law, Eunice Y.L.; Lin, J.; Hui, Christy Lai Ming; Chang, Wing Chung; Chan, Sherry K.W.; Chen, Eric

doi:10.1016/j.schres.2018.06.069

Cited by 10 publications

(8 citation statements)

References 10 publications

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“…tDCS has been used to improve functioning in patients with SSD in multiple tasks ( Chang et al , 2018 ; Gupta et al , 2018 ; Kennedy et al , 2018 ; Lee et al , 2018 ; Mellin et al , 2018 ; Mondino et al , 2018 ; Morgan and Singh, 2018 ; Sreeraj et al , 2018 ; Schülke and Straube, 2019 ); however, its effects on action-outcome monitoring have hitherto remained unexplored. Here, we provide some first insights into the effect of tDCS on the temporal prediction or monitoring of voluntary action outcomes in patients with SSD.…”

Section: Discussionmentioning

confidence: 99%

“…Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique increasingly used for modulation of central nervous system excitability in humans (see Woods et al , 2016 , for a review). Furthermore, the use of tDCS has been shown to improve performance in various tasks and can reduce symptoms in patients with schizophrenia (for reviews, see Gupta et al , 2018 ; Kennedy et al , 2018 ; Lee et al , 2018 ; Kostova et al , 2020 ). One general assumption is that anodal tDCS increases cortico-spinal excitability and cathodal tDCS decreases it ( Nitsche and Paulus, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

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Transcranial direct current stimulation improves action-outcome monitoring in schizophrenia spectrum disorder

Straube

Kemenade

Kircher

et al. 2020

Brain Communications

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Patients with schizophrenia spectrum disorder often demonstrate impairments in action-outcome monitoring. Passivity phenomena and hallucinations, in particular, have been related to impairments of efference copy-based predictions which are relevant for the monitoring of outcomes produced by voluntary action. Frontal transcranial direct current stimulation has been shown to improve action-outcome monitoring in healthy subjects. However, whether transcranial direct current stimulation can improve action monitoring in patients with schizophrenia spectrum disorder remains unknown. We investigated whether transcranial direct current stimulation can improve the detection of temporal action-outcome discrepancies in patients with schizophrenia spectrum disorder. On 4 separate days, we applied sham or left cathodal/right anodal transcranial direct current stimulation in a randomised order to frontal (F3/F4), parietal (CP3/CP4) and frontoparietal (F3/CP4) areas of 19 patients with schizophrenia spectrum disorder and 26 healthy control subjects. Action-outcome monitoring was assessed subsequent to 10 min of sham/transcranial direct current stimulation (1.5 mA). After a self-generated (active) or externally generated (passive) key press, subjects were presented with a visual outcome (a dot on the screen), which was presented after various delays (0–417 ms). Participants had to detect delays between the key press and the visual consequence. Symptom subgroups were explored based on the presence or absence of symptoms related to a paranoid-hallucinatory syndrome. In general, delay-detection performance was impaired in the schizophrenia spectrum disorder compared to the healthy control group. Interaction analyses showed group-specific (schizophrenia spectrum disorder vs healthy control group) and symptom-specific (with/without relevant paranoid-hallucinatory symptoms) transcranial direct current stimulation effects. Post-hoc tests revealed that frontal transcranial direct current stimulation improved the detection of long delays in active conditions and reduced the proportion of false alarms in undelayed trials of the passive condition in patients. The patients with no or few paranoid-hallucinatory symptoms benefited especially from frontal transcranial direct current stimulation in active conditions, while improvement in the patients with paranoid-hallucinatory symptoms was predominantly reflected in reduced false alarm rates in passive conditions. These data provide some first evidence for the potential utility of transcranial direct current stimulation in improving efference copy mechanisms and action-outcome monitoring in schizophrenia spectrum disorder. Current data indicate that improving efference copy-related processes can be especially effective in patients with no or few positive symptoms, while intersensory matching (i.e. task-relevant in passive conditions) could be more susceptible to improvement in patients with paranoid-hallucinatory symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcranial direct current stimulation improves action-outcome monitoring in schizophrenia spectrum disorder

Straube

Kemenade

Kircher

et al. 2020

Brain Communications

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“…Studies using HD-tDCS for PD are scarce so that it remains relatively unexplored whether this technique could produce better results compared to conventional tDCS. Similar to PD, the extant literature does not support the efficacy of tDCS for treating auditory hallucinations, a common symptom of schizophrenia [308]. However, two recent studies used HD-tDCS for auditory hallucinations with promising results [309, 310].…”

Section: Future Perspectivesmentioning

confidence: 99%

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Morya

Monte-Silva

Bikson

et al. 2019

J NeuroEngineering Rehabil

113

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Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. In this study, we present a comprehensive, integrative review of tDCS for motor rehabilitation and motor learning in healthy individuals, athletes and multiple neurologic and neuropsychiatric conditions. We also report on neuromodulation mechanisms, main applications, current knowledge including areas such as language, embodied cognition, functional and social aspects, and future directions. We present the use and perspectives of new developments in tDCS technology, namely high-definition tDCS (HD-tDCS) which promises to overcome one of the main tDCS limitation (i.e., low focality) and its application for neurological disease, pain relief, and motor learning/rehabilitation. Finally, we provided information regarding the Transcutaneous Spinal Direct Current Stimulation (tsDCS) in clinical applications, Cerebellar tDCS (ctDCS) and its influence on motor learning, and TMS combined with electroencephalography (EEG) as a tool to evaluate tDCS effects on brain function.

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“…, 2015 ), etc. It should be noted that tDCS may exert stronger effects in patients with psychiatry disorders such as autism and schizophrenia ( Lee et al. , 2018 ; Kim et al.…”

Section: Discussionmentioning

confidence: 99%

tDCS effect on prosocial behavior: a meta-analytic review

Yuan

Tolomeo

Yang

et al. 2021

Social Cognitive and Affective Neuroscience

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Previous studies have shown that transcranial direct current stimulation (tDCS) could potentially promote prosocial behaviors. However, results from randomized controlled trials (RCTs) are inconsistent. The current meta-analysis aimed to assess the effects of anodal and cathode tDCS using single session protocols on prosocial behaviors in healthy young adults, and explore potential moderators of these effects. The results showed that compared with sham stimulation, anodal (excitatory) stimulation significantly increased (g = 0.27, 95% CI [0.11, 0.43], Z = 3.30, p = 0.001) and cathodal (inhibitory) stimulation significantly decreased prosocial behaviors (g = -0.19, 95% CI [-0.39, -0.01], Z = -1.95, p = 0.051) using a multilevel meta-analytic model. These effects were not significantly modulated by stimulation parameters (e.g., duration, intensity and site) and types of prosocial behavior. The risk of publication bias for the included effects was minimal and no selective reporting (e.g., p-hacking) was found in the p-curve analysis. This meta-analysis showed that both anodal and cathode tDCS have small but significant effects on prosocial behaviors. The current study provides evidence that prosocial behaviors are linked to the activity of the ‘social brain’. Future studies are encouraged to further explore whether tDCS could effectively treat social dysfunctions in psychiatry disorders.

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Efficacy of transcranial direct current stimulation (tDCS) as a treatment for persistent hallucinations in patients with schizophrenia: A systematic review and meta-analysis

Cited by 10 publications

References 10 publications

Transcranial direct current stimulation improves action-outcome monitoring in schizophrenia spectrum disorder

Transcranial direct current stimulation improves action-outcome monitoring in schizophrenia spectrum disorder

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

tDCS effect on prosocial behavior: a meta-analytic review

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