Efficacy of trans-nasal fiberendoscopic injection laryngoplasty with centrifuged autologous fat in the treatment of glottic insufficiency due to unilateral vocal fold paralysis

Maccarini, Andrea Ricci; Stacchini, Marco; Mozzanica, Francesco; Schindler, Antonio; Basile, Eloisa; Rossi, G.; Woo, Peak; Remacle, Marc; Magnani, Massimo

doi:10.14639/0392-100x-2012

Cited by 19 publications

(45 citation statements)

References 31 publications

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“…However, nine of them were excluded because not all patients had UVFP and fat injection laryngoplasty combined with other treatments. Eleven clinical studies about autologous fat injection laryngoplasty for UVFP were reviewed [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], and the risk of bias for all articles is summarized in Figure 2 . Finally, seven studies were suitable for meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…All included articles were published between 2002 and 2020 [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], and the study characteristics were summarized in Table 1 . For the 11 included articles, there were three retrospective studies [ 13 , 14 , 21 ], and eight prospective studies [ 11 , 12 , 15 , 16 , 17 , 18 , 19 , 20 ] in Table 1 . A total of UVFP patients ( n = 337) received autologous fat injection laryngoplasty and were assessed for surgical outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…A total of UVFP patients ( n = 337) received autologous fat injection laryngoplasty and were assessed for surgical outcomes. The surgeries were undertaken under general [ 11 , 13 , 14 , 15 , 18 ] or local anesthesia [ 12 , 17 , 20 ], and the fat was harvested from the abdomen [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 19 , 20 , 21 ] or thigh area [ 14 ]. The harvested fat was managed by saline washing [ 11 , 13 , 16 , 17 , 19 ] or concentration [ 12 , 14 , 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…The surgeries were undertaken under general [ 11 , 13 , 14 , 15 , 18 ] or local anesthesia [ 12 , 17 , 20 ], and the fat was harvested from the abdomen [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 19 , 20 , 21 ] or thigh area [ 14 ]. The harvested fat was managed by saline washing [ 11 , 13 , 16 , 17 , 19 ] or concentration [ 12 , 14 , 15 ]. Four articles had no specific record [ 18 , 19 , 20 , 21 ], and seven articles used two approaches [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ], including trans-oral in two (28.57%) studies [ 11 , 16 ] and trans-cutaneous in five (71.42%) studies [ 12 , 13 , 14 , 15 , 17 ].…”

Section: Resultsmentioning

confidence: 99%

“…The harvested fat was managed by saline washing [ 11 , 13 , 16 , 17 , 19 ] or concentration [ 12 , 14 , 15 ]. Four articles had no specific record [ 18 , 19 , 20 , 21 ], and seven articles used two approaches [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ], including trans-oral in two (28.57%) studies [ 11 , 16 ] and trans-cutaneous in five (71.42%) studies [ 12 , 13 , 14 , 15 , 17 ]. In summary, the injection approach injected the 0.3–5 mL fat transcutaneously or transorally under the device guidance [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 19 ].…”

Section: Resultsmentioning

confidence: 99%

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Autologous Fat Injection Laryngoplasty for Unilateral Vocal Fold Paralysis

Chang

Chen

Tsai

et al. 2021

JCM

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Background: Unilateral vocal palsy (UVFP) affects the voice and swallowing function and could be treated by various materials to achieve improved mucosal wave and better closure during phonation. Injection laryngoplasty is considered an exemplary method for these patients and could be injected as early as possible. We conducted a systematic review and meta-analysis for the subjective and objective outcomes of autologous fat injection laryngoplasty (AFIL) and assessed the effects for patients with UVFP. Methods: We searched studies from PubMed and EBSCO databases with PRISMA appraisal to search for articles about the effects of AFIL on UVFP. The published articles were reviewed according to our inclusion and exclusion criteria. The short- and long-term outcomes of perceptual, acoustic analysis, and quality of life were also analyzed by meta-analysis. Results: Eleven articles were reviewed, and seven studies were selected for meta-analysis. AFIL improves the perceptual outcome and some voice parameters in short-term and long-term results, i.e., jitter, shimmer, and maximal phonation time (MPT). It also significantly improved the voice handicap index (VHI) in the long term, suggesting an increase in quality of life. Conclusions: AFIL is considered a reliable treatment method for UVFP and could even last for over 12 months.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Autologous Fat Injection Laryngoplasty for Unilateral Vocal Fold Paralysis

Chang

Chen

Tsai

et al. 2021

JCM

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Autologous Lipoaugmentation Long‐Term Clinical Outcomes: A Systematic Review

et al. 2021

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Objectives/Hypothesis Vocal fold (VF) lipoaugmentation can be employed to treat glottal insufficiency although variable data exist on its length of effectiveness. We aimed to review published long‐term outcomes following lipoaugmentation across the literature and compile outcome data. Study Design Systematic review. Methods A systematic search in September 2020 of PubMed, MEDLINE, Cochrane Library, and Web of Science used the Preferred Reporting Items for Systematic Review and Meta‐Analyses guidelines to identify 128 relevant articles related to VF lipoaugmentation effectiveness duration. Primary search terms included the following: vocal cord, fat, lipo, and atrophy. Forty‐eight full‐text articles were reviewed and 31 were included in the final analysis. Primary endpoints included the following: duration of effectiveness per patient‐reported outcome measures, objective findings, and additional procedures performed. In addition, fat harvest location and processing techniques were recorded. Findings Thirty‐one studies totaling 764 patients were included in the review. Indications for augmentation were VF paralysis (N = 690) and atrophy (N = 74). Fat was harvested from the abdominal region in 21 studies (529 patients), the thigh/abdomen in 5 studies (91 patients), and buccal/submental region in 2 studies (33 patients). Processing techniques and injectable volume varied. Across included studies, only 11 of 764 patients (1.4%) reported no improvement in voice and/or swallowing. Within the first year, 71 of 608 patients (11.7%) reported a regression toward baseline. Beyond 1 year and up to 8 years, 27 of 214 patients (12.6%) reported regression from initial improvement. Thirty‐three patients underwent additional procedures. Conclusion Although improvements in voice and swallowing after lipoaugmentation taper over time, most patients experienced long‐term benefit. Laryngoscope, 132:1042–1053, 2022

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Lipoinjection for Unilateral Vocal Fold Paralysis Treatment: A Systematic Review and Meta‐Analysis

et al. 2021

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Introduction: Lipoinjection is one of the available treatments for unilateral vocal fold paralysis. Objective: To evaluate lipoinjection predictability, and analyze the differences in safety and efficacy of the different techniques.Study Design: Systematic review and meta-analysis. Methods and Results: A systematic review on Medline, Cochrane, and Scopus databases included 49 articles analyzing the data of 1,166 patients, concerning technical details and voice parameters changes. Lipoinjection used a mean volume of 1.3 mL, 95% confidence interval (CI) (0.92, 1.69)-average overcorrection of 30%. Meta-analysis of pre-and postoperative voice parameters' means showed a significant improvement at 6 months of mean phonation time

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Efficacy of trans-nasal fiberendoscopic injection laryngoplasty with centrifuged autologous fat in the treatment of glottic insufficiency due to unilateral vocal fold paralysis

Cited by 19 publications

References 31 publications

Autologous Fat Injection Laryngoplasty for Unilateral Vocal Fold Paralysis

Autologous Fat Injection Laryngoplasty for Unilateral Vocal Fold Paralysis

Autologous Lipoaugmentation Long‐Term Clinical Outcomes: A Systematic Review

Lipoinjection for Unilateral Vocal Fold Paralysis Treatment: A Systematic Review and Meta‐Analysis

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