Efficacy of Tranquilizing and Antidepressant Drugs

Davis, John M.

doi:10.1001/archpsyc.1965.01730060070010

Cited by 77 publications

(16 citation statements)

References 241 publications

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“…The psychopharmacologic literature has been growing at a tremendous rate, that on tranquilizers alone comprising over five thousand references in 1965 according to Davis (1965).…”

Section: Scope Of This Reviewmentioning

confidence: 99%

Drug Effects on Learning in Children A Selective Review of the Past Thirty Years

Fréeman

1966

J Spec Educ

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“…The psychopharmacologic literature has been growing at a tremendous rate, that on tranquilizers alone comprising over five thousand references in 1965 according to Davis (1965).…”

Section: Scope Of This Reviewmentioning

confidence: 99%

Drug Effects on Learning in Children A Selective Review of the Past Thirty Years

Fréeman

1966

J Spec Educ

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“…4). We thought it would be worthwhile to investigate if there is any relationship between the capacity O-fr----,---~----,----_._---characteristics but moderate sedative properties (9). It was simultaneously injected (10 mg/kg) with theophylline and was found to significantly elevate blood levels of theophylline when compared with blood levels of animals injected with theophylline only.…”

Section: Resultsmentioning

confidence: 99%

Potentiation of blood antiasthmatic xanthine levels by tranquilizers in mice

Singh

d'Auteuil

Dufour

1976

European Journal of Drug Metabolism and Pharmacokinetics

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This study investigated in mice the interactions between drug, commonly used in chronic, multiple drug therapy in asthma. Pretreatment for three days with phenobarbital before injecting theophylline decreases blood xanthine levels. However, the phenothiazine derivatives, promazine or chlorpromazine when concurrently injected intraperitoneally with the xanthine derivatives, theophylline or aminophylline, elevated blood xanthine levels. These results suggest that certain phenothiazines may be of value in acute antiasthmatic therapy because they increase blood xanthine levels as well as being CNS depressants.Furthermore, phenothiazines in combination with aminophylline or theophylline in acute administration have the added advantage of markedly potentiating the increase in plasma cyclic AMP reflecting higher blood theophylline levels. It has been suggested that increased cyclic AMP may prevent the release of bronchoconstrictor substances by ensuring hte integrity of mast cells.

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“…Although MAO inhibiting drugs are useful in the treatment of some patients with depressive illness, not all compounds in this group are equally effective (45). It now seems possible that the therapeutic ineffectiveness of such MAO inhibitors as pargyline reflects its predominant action against MAOB (34).…”

Section: Functional Significancementioning

confidence: 99%

Monoamine Oxidases: the Present Status

Sandler¹,

Youdim²

1974

Int Pharmacopsychiatry

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The multiplicity of the insoluble mitochondrial enzyme, monoamine oxidase, has now been demonstrated in a variety of ways, indirectly by the use of selective inhibitors or directly (after solubilization), employing electrophoretic or immunochemical methods of separation. Although data obtained by these approaches may differ and are sometimes difficult to reconcile, evidence is continuing to accrue that the multiple forms are a true in vivo phenomenon and not merely preparation artefacts. Their functional significance and possible role in depressive illness have yet to be decided.

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Efficacy of Tranquilizing and Antidepressant Drugs

Cited by 77 publications

References 241 publications

Drug Effects on Learning in Children A Selective Review of the Past Thirty Years

Drug Effects on Learning in Children A Selective Review of the Past Thirty Years

Potentiation of blood antiasthmatic xanthine levels by tranquilizers in mice

Monoamine Oxidases: the Present Status

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