Efficacy of tranexamic acid in decreasing blood loss during cesarean section

Тарабрін, О. О.; Kaminskiy, V.V.; Галич, С Р; Ткаченко, Р.О.; Gulyaev, A; Shcherbakov, S; Gavrychenko, D.

doi:10.1186/cc11046

Cited by 4 publications

(3 citation statements)

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“…We identified 31 reports describing 26 trials involving a total of 4191 women (Figure S1). The trial reports were published between 2001 and 2015.…”

Section: Resultsmentioning

confidence: 99%

Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials

Ker

Shakur

Roberts

2016

BJOG

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“…We identified 31 reports describing 26 trials involving a total of 4191 women (Figure S1). The trial reports were published between 2001 and 2015.…”

Section: Resultsmentioning

confidence: 99%

Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials

Ker

Shakur

Roberts

2016

BJOG

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“…Out of the three trials two were those who had caesarean section delivery 9,10 and one who had spontaneous vaginal delivery. 11 Combining the results of the three trials, use of TXA significantly reduced mean blood loss by 92 ml (95% CI 76 to 109) compared to no treatment. There were no mortality and no thrombotic event was reported.…”

Section: Discussionmentioning

confidence: 99%

Patients Knowledge and Opinion of in-Office and Home Bleaching in Riyadh Elm University Clinics

Alshammrani¹

2021

IJMBS

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A dull smile has social repercussions. Demand for improved and beautiful smile has become an integral part of dental procedures (AlOtaibi et al., 2020). A large number of people, especially young females are concerned of their smiles and this is because of the reason that the first thing people notice when meeting a new person is their smile (Alshamrani and Wahid, 2018). In the present era, patients are increasingly demanding for a perfect smile due to a shift in priorities and the impact of the media (Hatherell et al., 2011, Pretty et al., 2006).

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“…Despite significant progress in obstetric care, 125,000 women die from obstetric haemorrhage annually in the world. 1 The lower segment cesarean section (LSCS) is an established procedure. It involves a transverse incision on the lower uterine segment which is easier to repair and heal well.…”

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confidence: 99%

Comparative Study of Intravenous Tranexamic Acid and Oxytocin Versus Oxytocin Alone in Reducing Blood Loss During and After LSCS Under Spinal Anaesthesia

Ray¹,

Mondal²

2019

jebmh

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BACKGROUND Cesarean section (CS) rates have been increased to as high as 25 to 30% in many areas of the world. Risk of postpartum haemorrhage increases in cases of cesarean section & PPH is a major cause of maternal morbidity & mortality. Routinely uterotonics are used for active management of third stage of labour. Tranexamic acid by its antifibrinolytic action further reduces blood loss. This study will evaluate the efficacy and safety of tranexamic acid in combination with uterotonic drugs in reducing the blood loss after placental delivery following lower segment caesarean section (LSCS). METHODS A randomized, case controlled, prospective study was conducted on 100 women undergoing lower segment cesarean section (LSCS) at term between 37 and 41 wks. and have been studied prospectively. They are divided in two groups, 50 control &50 cases. Cases (50) were given tranexamic acid immediately before LSCS along with 10 units of oxytocin whereas control group were given 10 units of oxytocin alone after delivery of foetus. Blood loss was collected and measured during two periods. RESULTS The patient characteristics, namely age, height, weight, gestational age and gravidity in two groups were similar which was statistically insignificant. There was no episode of thrombosis in the study. Tranexamic acid significantly reduced the quantity of the blood loss from time of placental delivery to 2 hours postpartum (p<0.001) and from end of LSCS to 2 hours postpartum (p<0.001). However there was no statistical difference in quantity of blood loss from time of placental delivery to end of LSCS in both groups. CONCLUSIONS A safe dose of Tranexamic acid has an effective role in reducing blood loss during LSCS without causing adverse reaction. Thus the drug can be used effectively in reducing maternal morbidity and mortality during LSCS.

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Efficacy of tranexamic acid in decreasing blood loss during cesarean section

Cited by 4 publications

References 0 publications

Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials

Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials

Patients Knowledge and Opinion of in-Office and Home Bleaching in Riyadh Elm University Clinics

Comparative Study of Intravenous Tranexamic Acid and Oxytocin Versus Oxytocin Alone in Reducing Blood Loss During and After LSCS Under Spinal Anaesthesia

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