Efficacy of topical tacrolimus 0.3% in clobetasol propionate 0.05% ointment in therapy-resistant cutaneous lupus erythematosus: a cohort study

Abstract

The results of our small retrospective study suggest that TCPO may be more effective than either 0.1% tacrolimus or clobetasol propionate 0.05% ointment monotherapy in the treatment of recalcitrant CLE. Randomized controlled trials are needed to confirm these preliminary findings.

Treatment of Cutaneous Lupus

“…A more recent double-blind, vehicle-controlled randomized trial evaluated tacrolimus 0.1% ointment in different CLE subtypes and demonstrated a significantly higher response rate in patients treated with tacrolimus 0.1% compared to the vehicle [5]. There is also data to suggest that the combination of tacrolimus and clobetasol is more effective than tacrolimus alone [14]. …”

Efficacy of tacrolimus 0.1% ointment in cutaneous lupus erythematosus: A multicenter, randomized, double-blind, vehicle-controlled trial

“…eblue.org). [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Most of the published studies have an open-label design, involving only a small number of patients and no vehicle or control group. To date, the only randomized, double-blind study compared 0.1% tacrolimus ointment with 0.05% clobetasol in 15 patients with facial CLE.…”

Treatment of Scarring Alopecia in Discoid Variant of Chronic Cutaneous Lupus Erythematosus With Tacrolimus Lotion, 0.3%

“…11 In contrast to corticosteroids-which nonselectively affect epidermal and dermal cells-topical tacrolimus spares keratinocytes, fibroblasts, and endothelial cells, precluding the more robust adverse effects seen with corticosteroids. 12 Topical tacrolimus ointment has demonstrated mixed success in treating DLE lesions of the face and scalp as outlined in 2 in which a higherpotency tacrolimus ointment, 0.3%, was compounded with clobetasol propionate with a good clinical response. However, the inclusion of a corticosteroid obscures the precise role of tacrolimus and potentially begets a similar adverse effect profile to that of corticosteroids used alone.…”