Efficacy of topical Rose ( Rosa damascena Mill.) oil for migraine headache: A randomized double-blinded placebo-controlled cross-over trial

Niazi, Maria; Hashempur, Mohammad Hashem; Taghizadeh, Mohsen; Heydari, Mojtaba; Shariat, Abdolhamid

doi:10.1016/j.ctim.2017.07.009

Cited by 58 publications

(53 citation statements)

References 29 publications

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“…Likewise, the impact of rose on the intensity of pain was studied among migraine patients, which indicated that the severity of pain decreases as time goes on [9]. Similarly, when lavender extract is taken orally, it can gradually reduce the pain and frequency of migraine attacks by the passage of time and higher doses [10].…”

Section: Discussionmentioning

confidence: 99%

“…Studies have also shown that topical use of herbal drugs can have a beneficial effect on neuropsychological diseases. In addition, these extracts may stimulate the olfactory pathway of the central nervous system as an additional mechanism to reduce response to a painful stimulus [10].…”

Section: Pairwise Comparisonsmentioning

confidence: 99%

“…None of the above medications works satisfactorily for the management of migraine attacks [1,[8][9][10]. Insufficient treatment of migraine can increase the risks of developing chronic migraine by 2.5-3.5 times [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…CAM has lesser-known side effects with fewer dependency on medication [17]. Existing literature shows promising effectiveness for the treatment of migraines [10,[18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

et al. 2020

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Objective: Complementary therapies have been increasingly used for the prevention and treatment of migraine so that there is a need for studies in this setting. This study sought to determine the effects of basil essential oil on the severity and frequency of migraine attack headaches. Methods: A triple-blind clinical trial study was performed on 144 patients diagnosed with migraine. Patients were randomly allocated by a stratified method to four groups of 36 titled basil essential oil 2, 4, 6%, and placebo groups. Medications were used topically every 8 h for 3 successive months. In addition, each individual received 325 mg of acetaminophen every 12 h. The severity and frequency of migraine attacks were measured prior to the study, at weeks 2, 4, 8, and 12. The visual analog scale was used to measure pain intensity. The marginal model and generalized estimation equations were used to compare changes in the intensity and frequency of pain over time. Results: The interaction of the dose and time factors was significant on both pain intensity (p < 0.001) and frequency of attack (p < 0.001). The odds ratio of higher pain intensity and rate ratio of higher frequency of attack in the intervention groups compared to the placebo group were decreased over the study time. Conclusion: Time lapse and higher doses of basil essential oil would reduce both the intensity and frequency of migraine attacks.

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Section: Discussionmentioning

confidence: 99%

Section: Pairwise Comparisonsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

et al. 2020

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“…Besides increasing attentiveness toward complementary and alternative medicine (Niazi, Hashempur, Taghizadeh, Heydari, & Shariat, 2017), there are several herbal remedies that reveal probable advantage for management of renal stones. Some of the commonly used herbs were Ammi visnaga, Tribulus terrestris, Bergenia ligulata, Vediuppu chunnam, Dolichos biflorus, and Paronychia argentea (Yadav et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double‐blind, placebo‐controlled, clinical trial

Movaghati

Yousefi

Saghebi³

et al. 2019

Phytotherapy Research

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Preclinical studies have shown beneficial effects of black seed (Nigella sativa L.) in the prevention and treatment of renal stones. Hence, we designed a study to evaluate the renal‐stone‐dissolving efficacy of black seed. Sixty patients with renal stones were randomly enrolled in two arms of a randomized, triple‐blind, placebo‐controlled, clinical trial. The patients were treated by black seed capsules (500 mg) or placebo two times per day for 10 weeks. Patients were assessed in terms of size of renal stones by using sonography before and after intervention. In the black seed group, 44.4% of patients excreted their stones completely, and the size of the stones remained unchanged and decreased in 3.7% and 51.8% of patients, respectively. In contrast, in the placebo group, 15.3% of the patients excreted their stones completely, 11.5% had reduction in stone size, 15.3% had increase in stone size, and 57.6% had no change in their stone size. The difference in the mean size of renal stones after the study was significant between the two groups (p < 0.05). N. sativa L., as compared with placebo, is demonstrated to have significant positive effects on disappearance or reduction of size of kidney stones.

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Acute Treatments for Episodic Migraine in Adults

VanderPluym

Singh

Urtecho

et al. 2021

JAMA

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IMPORTANCEMigraine is common and can be associated with significant morbidity, and several treatment options exist for acute therapy.OBJECTIVE To evaluate the benefits and harms associated with acute treatments for episodic migraine in adults.DATA SOURCES Multiple databases from database inception to February 24, 2021.STUDY SELECTION Randomized clinical trials and systematic reviews that assessed effectiveness or harms of acute therapy for migraine attacks.DATA EXTRACTION AND SYNTHESIS Independent reviewers selected studies and extracted data. Meta-analysis was performed with the DerSimonian-Laird random-effects model with Hartung-Knapp-Sidik-Jonkman variance correction or by using a fixed-effect model based on the Mantel-Haenszel method if the number of studies was small. MAIN OUTCOMES AND MEASURESThe main outcomes included pain freedom, pain relief, sustained pain freedom, sustained pain relief, and adverse events. The strength of evidence (SOE) was graded with the Agency for Healthcare Research and Quality Methods Guide for Effectiveness and Comparative Effectiveness Reviews.FINDINGS Evidence on triptans and nonsteroidal anti-inflammatory drugs was summarized from 15 systematic reviews. For other interventions, 115 randomized clinical trials with 28 803 patients were included. Compared with placebo, triptans and nonsteroidal anti-inflammatory drugs used individually were significantly associated with reduced pain at 2 hours and 1 day (moderate to high SOE) and increased risk of mild and transient adverse events. Compared with placebo, calcitonin gene-related peptide receptor antagonists (low to high SOE), lasmiditan (5-HT 1F receptor agonist; high SOE), dihydroergotamine (moderate to high SOE), ergotamine plus caffeine (moderate SOE), acetaminophen (moderate SOE), antiemetics (low SOE), butorphanol (low SOE), and tramadol in combination with acetaminophen (low SOE) were significantly associated with pain reduction and increase in mild adverse events. The findings for opioids were based on low or insufficient SOE. Several nonpharmacologic treatments were significantly associated with improved pain, including remote electrical neuromodulation (moderate SOE), transcranial magnetic stimulation (low SOE), external trigeminal nerve stimulation (low SOE), and noninvasive vagus nerve stimulation (moderate SOE). No significant difference in adverse events was found between nonpharmacologic treatments and sham.CONCLUSIONS AND RELEVANCE There are several acute treatments for migraine, with varying strength of supporting evidence. Use of triptans, nonsteroidal anti-inflammatory drugs, acetaminophen, dihydroergotamine, calcitonin gene-related peptide antagonists, lasmiditan, and some nonpharmacologic treatments was associated with improved pain and function. The evidence for many other interventions, including opioids, was limited.

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Efficacy of topical Rose ( Rosa damascena Mill.) oil for migraine headache: A randomized double-blinded placebo-controlled cross-over trial

Cited by 58 publications

References 29 publications

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution: A randomized, double‐blind, placebo‐controlled, clinical trial

Acute Treatments for Episodic Migraine in Adults

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