Efficacy of topical honey therapy against silver sulphadiazine treatment in burns: A biochemical study

Nagane, N. S.; Ganu, Jayashree V.; Bhagwat, Vinod R; Subramanium, M.

doi:10.1007/bf02894280

Cited by 14 publications

(8 citation statements)

References 9 publications

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“…The average duration of wound healing in patients in the honey group coming within 1 hour, 2-8 hours, [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] hours and more than 48 hours was 18.8, 17.8, 21.25 and 14.25 days, respectively. Among patients in the SSD group, average duration of healing was 27.6, 32.4, 32.5, 32.5 and 38.6 days for similar times of reporting [ Table 3].…”

Section: Resultsmentioning

confidence: 99%

A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients

Baghel

Shukla

Mathur

et al. 2009

Indian J Plast Surg

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To compare the effect of honey dressing and silver-sulfadiazene (SSD) dressing on wound healing in burn patients. Patients (n=78) of both sexes, with age group between 10 and 50 years and with first and second degree of burn of less than 50% of TBSA (Total body surface area) were included in the study, over a period of 2 years (2006-08). After stabilization, patients were randomly attributed into two groups: ‘honey group’ and ‘SSD group’. Time elapsed since burn was recorded. After washing with normal saline, undiluted pure honey was applied over the wounds of patients in the honey group (n=37) and SSD cream over the wounds of patients in SSD group (n=41), everyday. Wound was dressed with sterile gauze, cotton pads and bandaged. Status of the wound was assessed every third and seventh day and on the day of completion of study. Patients were followed up every fortnight till epithelialization. The bacteriological examination of the wound was done every seventh day. The mean age for case (honey group) and control (SSD group) was 34.5 years and 28.5 years, respectively. Wound swab culture was positive in 29 out of 36 patients who came within 8 hours of burn and in all patients who came after 24 hours. The average duration of healing in patients treated with honey and SSD dressing at any time of admission was 18.16 and 32.68 days, respectively. Wound of all those patients (100%) who reported within 1 hour became sterile with honey dressing in less than 7 days while none with SSD. All of the wounds became sterile in less than 21 days with honey, while tthis was so in only 36.5% with SSD treated wounds. The honey group included 33 patients reported within 24 hour of injury, and 26 out of them had complete outcome at 2 months of follow-up, while numbers for the SSD group were 32 and 12. Complete outcome for any admission point of time after 2 months was noted in 81% and 37% of patients in the honey group and the SSD group. Honey dressing improves wound healing, makes the wound sterile in lesser time, has a better outcome in terms of prevention of hypertrophic scarring and post-burn contractures, and decreases the need of debridement irrespective of time of admission, when compared to SSD dressing.

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Section: Resultsmentioning

confidence: 99%

A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients

Baghel

Shukla

Mathur

et al. 2009

Indian J Plast Surg

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“…Besides the anti-infectious activity of honey, a lot of studies highlighted its anti-inflammatory, anti-edematous and anti-exudative activities, as shown by assessment of wound evolution [30,[43][44][45][46][47][48], biochemical tests of indicators of inflammation (decreased malondialdehyde and lipid peroxide levels) [49][50][51] and histopathology exams (decrease of inflammatory cells) [43].…”

Section: The Anti-inflammatory Activity Of Honeymentioning

confidence: 99%

Honey, Food and Medicine: Scientific Rationale and Practical Efficiency in External Administration of Medicinal Honey for Wound Healing

Zbuchea¹

2017

JAST-B

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Except for its benefits as food and medicine, honey has been used since ancient times as an external remedy in wound care, and has been the subject of numerous studies and research, that reveal its complex favorable action for wound healing. Based on scientific research and clinical studies published in literature, this work presents these various properties and therapeutic activities of honey dressings. Next, actions and clinical effects of L-Mesitran range of dressings, based on medicinal honey and authorized European Union (EU) and Food and Drug Administration (FDA), have been highlighted in a case series of patients in the Department of Plastic Surgery, Emergency District Hospital of Ploiesti, Romania, by monitoring the clinical local evolution of burns and other wounds. L-Mesitran range of products is based on the combination of medicinal honey and other ingredients, such as hypoallergenic medicinal lanolin, vitamins C and E. These sterilized preparations were applied for various skin lesions after wound cleansing, and exerted a favorable action on healing of burns and other wounds, sometimes in combination with surgical treatment, being applied in these cases before or after surgery. Further clinical studies are needed to establish the best indications, methods and forms of administration for each type of wounds, as well as the selection over other types of dressings.

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“…The very large body of clinical evidence for the effectiveness of honey in heaHng wounds has been reviewed [127 1 , The evidence covered in that review, plus that from trials published since the review was published [128][129][130][131][132][133][134], is from 23 randomized controlled trials involving a total of 2257 participants, seven clinical trials of other forms involving 142 participants treated with honey, four case studies where there were multiple wounds allowing comparison of honey with other treatment and 16 trials of honey on a total of 533 wounds in animal models (which rule out a placebo effect). Mostly the wounds involved were infected.…”

Section: Clinical Evidence For Effectiveness Of Honey On Infected Woundsmentioning

confidence: 99%

Honey: Antimicrobial Actions and Role in Disease Management

Molan

2008

New Strategies Combating Bacterial Infection

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The ancient treatment of dressing infected wounds wi.th honey is rapidly becoming re-established in professional medicine, especially where wounds are infected with antibiotic-resistant bacteria. This is because ofthe demonstrated sensitivity of such bacteria to the antibacterial activity ofhauey, which is not influenced by whether or not strains are resistant to antibiotics. Honey has been found to have a very broad spectrum of activity, but its potency of antibacterial activity can vary greatly. In most honeys the antibacterial activity is due to enzymatically produced hydrogen peroxide and thus the potency of its antibacterial activity can be decreased by catalase present in an open wound. Manuka honey has an antibacterial component derived from the plant source. Manuka honey with a quality-assured level of antibacterial activity is being used by companies marketing honey products for wound care that are registered with the medical regulatory authorities in various countries. Such honey can be diluted IO-fold or more and still completely inhibitthe usual wound-infecting species. There is a large amount of clinical evidence for the effectiveness of honey in clearing infection in wounds, and some clinical evidence of its effectiveness in treating other infections. Although the antibacterial potency of honey is insufficient to allow its use systemically, there are various clinical applications besides wound care in which it is used topically or where it does not get excessively diluted, such as for treatment of gastritis, enteritis, gingivitis, ophthalmological infections and bronchial infections. In most of these applications the anti-inflammatory activity of honey is of additional benefit in decreasing the inflammation resulting from infection. Additional clinical research is needed to provide better evidence of the effectiveness of honey in these therapeutic applications of honey.New Strategies CombClting Bacterial Infection. Edited by Iqbal Ahmad and Farrukh Aqii

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Efficacy of topical honey therapy against silver sulphadiazine treatment in burns: A biochemical study

Cited by 14 publications

References 9 publications

A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients

A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients

Honey, Food and Medicine: Scientific Rationale and Practical Efficiency in External Administration of Medicinal Honey for Wound Healing

Honey: Antimicrobial Actions and Role in Disease Management

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