Efficacy of topical honey compared to systemic gentamicin for treatment of infected war wounds in a porcine model: A non-inferiority experimental pilot study
Abstract:Background: In armed conflicts, infected wounds constitute a large portion of the surgical workload. Treatment consists of debridements, change of dressings, and antibiotics. Many surgeons advocate for the use of honey as an adjunct with the rationale that honey has bactericidal and hyperosmotic properties. However, according to a Cochrane review from 2015 there is insufficient data to draw any conclusions regarding the efficacy of honey in treatment of wounds. We, therefore, decided to evaluate if honey is no… Show more
“…10 Normally, using antibiotics as adjuvant therapy in serious wounds is necessary. [11][12][13] However, because of the nonspecific…”
Section: Introductionmentioning
confidence: 99%
“…Normally, using antibiotics as adjuvant therapy in serious wounds is necessary. 11–13 However, because of the nonspecific killing action of antibiotics, their use leads to a drastic depletion of probiotics and a major setback for the curative effect. Hence, improving the survival ability of probiotics in trauma sites is crucial for achieving a curative effect.…”
Living probiotics secrete bioactive substances to accelerate wound healing, but the clinical application of antibiotics inhibits the survival of probiotics. Inspired by the chelation of tannic acid and ferric ions,...
“…10 Normally, using antibiotics as adjuvant therapy in serious wounds is necessary. [11][12][13] However, because of the nonspecific…”
Section: Introductionmentioning
confidence: 99%
“…Normally, using antibiotics as adjuvant therapy in serious wounds is necessary. 11–13 However, because of the nonspecific killing action of antibiotics, their use leads to a drastic depletion of probiotics and a major setback for the curative effect. Hence, improving the survival ability of probiotics in trauma sites is crucial for achieving a curative effect.…”
Living probiotics secrete bioactive substances to accelerate wound healing, but the clinical application of antibiotics inhibits the survival of probiotics. Inspired by the chelation of tannic acid and ferric ions,...
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